Dabsence of cell wall Submit DGolgi bodies Submit DAll of these Submit Assertion: Members of a species are reproductively isolated from others belonging to other species. Reason: Species is the basic taxonomic category. View Solution What would be the number of chromosomes in the cell of the ...
Proneural gliomas can arise from transformation of glial progenitors that are driven to proliferate via mitogenic signaling that affects translation. To investigate translational regulation in this system, we developed a RiboTag glioma mouse model that enables cell-type-specific, genome-wide ribosome ...
REMD can be mechanistically distinguished from other surveillance pathways by its functional linkage to accelerated deadenylation, by its independence from the NMD factor Upf1 and by cell-type restriction. This unusual pathway of mRNA surveillance is likely to act as a modifier of additional genetic ...
Cotranslational response to proteotoxic stress by elongation pausing of ribosomes. Mol. Cell 49, 453–463 (2013). Article CAS Google Scholar Lintner, N. G. et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 15, e2001882 ...
3A). But, cells possessing a nucleoplasmic pool of Arf below that suited for timely cell cycle entry might attain the cyclin E–Cdk threshold prematurely. They might, then, venture to cross the R point before having completed events prerequisite for their successful division, which would ...
The ribosome has long been considered as a consistent molecular factory, with a rather passive role in the translation process. Recent findings have shifted this obsolete view, revealing a remarkably complex and multifaceted machinery whose role is to or
The major advantage of TRAP-seq lies in its ability to allow translational evaluation of specific cell types within tissues [25], which is beyond the capabilities of the other three translatomic techniques. For example, TRAP-seq has been used for cell type-specific expression profiling in repopul...
Articulatin-D, a 66kDa ribosome inactivating protein (RIP) comprised of 29kDa A-chain linked to 35kDa B-chain, is purified from leafless mistletoe ( against different cancer cell lines (Jurkat: 0.31±0.02nM, MOLT-4: 0.51±0.03nM, U-937: 0.64±0.07nM, HL-60: 0.79±0.11nM, Raji: 1....
Let’s answer some basic questions first before moving ahead to the intricacies of the topic. What is a ribosome? Answer: Ribosome is a cell organelle that’s cytoplasmic in nature and also called the protein factory of the cell. What do ribosomes do? Answer: Ribosomes serve as the synthe...
Similarly, almost no function within the cell can proceed without the input of energy. As a result, all signal transduction pathways in the cell and the status of the epigenome are modulated by phosphorylation by ATP and/or acetylation by acetyl-CoA, both of which are primarily generated by ...