Ribosome Protein Chapters and Articles You might find these chapters and articles relevant to this topic. Chapter Ribosomes The identification and number of ribosomal proteins The ribosome has a large number of
A. Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis. Nucleic Acids Res. 39, 2445–2457 (2011). CAS PubMed Google Scholar Zheng, S., Lan, P., Liu, X. & Ye, K. Interaction between ribosome assembly factors Kr...
Note that disruption of ribosome biogenesis at different stages leads to different syndromes. Given the importance of the ribosome in protein synthesis, which is a basal, global process vital for cell survival and proliferation, it is remarkable that mutations in genes disrupting the process of ...
Their function during ribosome biogenesis is not fully understood, however EMG1 also functions as a methyltransferase, which catalyses the N1‐methylation of U1240 in the 18 S rRNA36. Notably, the previously uncharacterised KSHV protein, ORF11, was also shown to associate with pre-40S ...
(Karbstein2007; Koller-Eichhorn et al.2007). The Obg (Spo0B-associated GTP-binding protein) subfamily of GTPases has been the recent interest in studies for the biogenesis of prokaryotic ribosomes (Maouche et al.2016; Zielke et al.2015; Feng et al.2014). InEscherichia coli, ...
Notably, the top hits included proteins crucial for 40S ribosome biogenesis, such as nucleolar complex protein 4 homolog (NOC4L), bystin-like (BYSL), EMG1, poly(A)-specific ribonuclease (PARN), ribosomal RNA processing 12 homolog (RRP12) and DEAH-box helicase 37 (DHX37) (Fig. 4A). ...
Defects in ribosome biogenesis result in a nucleolar stress response involving the TP53 tumor suppressor protein and impaired protein synthesis leading to a deregulated translational output. Despite the accepted notion that ribosomes are omnipresent and essential for all cells, most ribosomopathies show ...
S4C), which is likely through the decreased protein level of DIMT1. We observed decreased cell proliferation in DIMT1+/− heterozygous compared with WT cells (Fig. 2D). These results are consistent with the fact that DIMT1 is important for 18S rRNA processing and the biogenesis of the ...
Figure 7. Architecture, Dynamic Formation, and Processing of the 90S Pre-ribosome during Early Ribosome Biogenesis (A) Cryo-EM model of the ct90S pre-ribosome (front and back view) with all the identified factors and RNA as described in the text. (B) Schematic model of the 90S pre-riboso...
Given the importance of the ribosome inprotein synthesis, which is a basal, global process vital for cell survival and proliferation, it is remarkable that mutations in genes disrupting the process of ribosome biogenesis result in congenital disorders with tissue-specific defects. Studies of these uni...