We report here that in rat and human neuroprogenitor cells as well as rat embryonic cortical neurons Zika virus (ZIKV) infection leads to ribosomal stress that is characterized by structural disruption of the n
The majorities of colorectal cancer (CRC) cases are sporadic in origin and a large proportion of etiologies are associated with environmental stress responses. In response to external and internal stress, the ribosome stands sentinel and stress-driven ribosomal dysfunction triggers the cellular decision...
Corbo, E. Imperlini et al., "Differential pro- teomic analysis in human cells subjected to ribosomal stress," Proteomics, vol. 13, no. 7, pp. 1220-1227, 2013.Caterino M, Corbo C, Imperlini E, Armiraglio M, Pavesi E, Aspesi A, et al. Differential proteomic analysis in human cells...
This article offers a review on the extra-ribosome functions of the ribosomal proteins in ribosomal stress signaling, normal development, tumorigenesis, and genetic diseases, and a prospective on their clinical significance as potential anti-disease therapeutic targets. View chapter Reference work 2023, ...
Ribotoxic stress response: Activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the alpha-sarcin/ricin loop in the 28S rRNA Mol. Cell. Biol., 17 (1997), pp. 3373-3381 View in ScopusGoogle Scholar 11...
Tak1 signaling regulates p53 through a mechanism involving ribosomal stress [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS19-21. 展开 ...
This review article explores the intricate role, and regulation of ribosomal protein in response to stress, particularly emphasizing their pivotal role to
(2003) Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway. Mol Cell Biol 23: 8902–8912. [15] Gilkes DM, Chen L, Chen J (2006) MDMX regulation of p53 response to ribosomal stress. EMBO J 25: 5614–5625. [16] Dai ...
p53-mediated nucleolar stress response. Cell growth and proliferation remain under constant nucleolar surveillance. Under normal growth conditions, levels of the tumor suppressor p53 are suppressed by the binding of the E3 ubiquitin ligase mouse double minute 2 (Mdm2) and its homolog Mdm4, leading ...
DBA is most often due to heterozygous mutations in ribosomal protein (RP) genes that lead to defects in ribosome biogenesis and function and result in ribosomal stress and p53 activation. The molecular mechanisms underlying this pathology are still poorly understood and studies on patient erythroid ...