MDMX regulation of p53 response to ribosomal stress. EMBO J 2006 ; 25:5614 - 5625; PMID: 17110929 ; http://dx.doi.org/ 10.1038/sj.emboj.7601424Gilkes DM, Chen L, Chen J. 2006. MDMX regulation of p53 response to ribosomal stress . EMBO J. 25 :5614–5625. 10.1038/sj.emboj.7601424...
We report here that in rat and human neuroprogenitor cells as well as rat embryonic cortical neurons Zika virus (ZIKV) infection leads to ribosomal stress that is characterized by structural disruption of the nucleolus. The anti-nucleolar effects were most pronounced in postmitotic neurons. Moreover...
Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors 来自 EBSCO 喜欢 0 阅读量: 57 作者:S Hubackova,E Davidova,S Boukalova,J Kovarova,J Neuzil 摘要: p53-mutated tumors often exhibit increased resistance to standard ...
Tak1 signaling regulates p53 through a mechanism involving ribosomal stress [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS19-21. 展开 ...
This article offers a review on the extra-ribosome functions of the ribosomal proteins in ribosomal stress signaling, normal development, tumorigenesis, and genetic diseases, and a prospective on their clinical significance as potential anti-disease therapeutic targets. View chapterExplore book Ribosome ...
The induction of p53 following ribosomal stress may have a more complicated mechanism, and further investigation is needed to determine the mechanism whereby RP deletion leads to p53 induction. Intracellular RPs are very abundant proteins, that bind to various RNA molecules and protein complexes out...
p53-mediated nucleolar stress response. Cell growth and proliferation remain under constant nucleolar surveillance. Under normal growth conditions, levels of the tumor suppressor p53 are suppressed by the binding of the E3 ubiquitin ligase mouse double minute 2 (Mdm2) and its homolog Mdm4, leading ...
IPO7 and XPO1 for nuclear import and export signals regulate ribosomal stress [34]. In the present study, combined treatment of melatonin (3 mM) and puromycin (1 μM) synergistically attenuated the expression of 45S pre-rRNA and UBF, suppressed cell viability, and also consistently ...
The duplication and divergence of heat stress (HS) response genes might help plants adapt to varied HS conditions, but little is known on the topic. Here, ... C Hu,SY Lin,CYY Charng - 《Plant Physiology》 被引量: 79发表: 2012年 ...
Furthermore, profound increases in the intensity of nuclear p53 in shScr þ H (2.1-fold increase) or shScr þ A (4.4-fold increase) compared with that of shGLT þ H or shGLT þ A, respectively, support the importance of GLTSCR2 in p53 regulation under ribosomal stress. Consistent...