This paper aims to elucidate the regulatory effects of BMAL1, clock and other clock genes on immune cells, and reveal the molecular mechanism of circadian rhythm’s involvement in tumor and its microenvironment regulation. A deeper understanding of circadian rhythms has the potential to provide new...
Statistical analyses were calculated by SPSS Statistics version 29.0.2.0 (IBM Corporation, Armonk, NY, USA). All results are displayed as mean values with the standard deviation (SD) and percentages of the whole. As group sizes are unbalanced due to the retrospective character of the study, Gau...
Almost all physiological activities of mammals are regulated by the body’s biological clock, including sleep-wake, eating-fasting, and activity-rest cycle [2]. Its master clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which can process light input signals and transmit...
Time to check your body clock? We all have unique biological rhythms that impact energy, focus and performance. Learn more about yours in 60 seconds. Take QuizDownload Sign Up Sign Up FOLLOW US DOWNLOAD NOW
] 37.A.mend B.check C.examine D.repair C [司机赶紧刹车,然后下车“仔细检查”所有车胎。check 指“校对,找错”;而 examine 指“查看以了解情况”。] 38.A.that B.what C.about D.why B [她没敢告诉这位司机刚才听到的是“什么”声音。] 39.A.for B.yet C.but D.so D [司机没...
L. et al. Coordination of the transcriptome and metabolome by the circadian clock. Proc. Natl Acad. Sci. USA 109, 5541–5546 (2012). 19. Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M. & Sassone-Corsi, P. Circadian control of the NAD þ salvage pathway by CLOCK-SIRT1....
Circadian rhythm (CR) disturbance is intricately associated with Parkinson’s disease (PD). However, the involvement of CR-related mechanisms in the pathogenesis and progression of PD remains elusive. A total of 141 PD patients and 113 healthy participan
Therefore, the interaction between the circadian clock and the ERK/MAPK pathway can serve as a target for improving myelin repair in demyelinating regions. Melatonin and BMAL1 both increase the phosphorylation of AKT, ERK-1/2, PDK1, mTOR, PTEN, GSK-3αβ, and p70S6K (Beker et al., 2019...
A day–night (or light–dark) circadian rhythm (biological clock) is synchronized by a process that is coordinated by the pineal gland, which produces and releases melatonin into peripheral blood (PB) [1]. Thus, melatonin is a well-defined biochemical coordinator of circadian rhythms [2,3,4...
Within this context, the circadian clock has been implicated in DNA damage response (DDR), including cell cycle checkpoints and DNA repair. DNA damage-induced cell cycle checkpoints are signal transduction pathways driven by DNA damage, acting as a genome surveillance mechanism to ensure genomic in...