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(2017). Rho GTPase-activating proteins: Regulators of Rho GTPase activity in neuronal development and CNS diseases. Mol Cell Neurosci 80, 18-31.Huang G-H, Sun Z-L, Li H-J, Feng D-F. Rho GTPase- activating proteins: Regulators of Rho GTPase activity in neuronal development and CNS ...
在细胞骨架的结构上,Rho-GTPase蛋白起到了决定作用。当这些分子开关被激活时,它们向细胞骨架上的机器发出指令。有145种Rho-GTPase调控蛋白控制这些分子开关:RhoGEF(guanine nucleotide exchange factors)类蛋白打开它们,RhoGAP(GTPase-activating proteins)类蛋白关闭它们。现在,Rocks和他的团队首次系统地调查了所有这些调控...
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate. 应用类型 WB 免疫原 ARHGAP1 来源宿主 兔 反应性 人 保存建议 建议收到该Rho GTPase Activating Protein 1 (ARHGAP1) Antibody产品后,储存温度...
RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM].
Rho-GTPase activity is modulated by guanine nucleotide-dissociation inhibitors (GDIs), guanine nucleotide-exchange factors (GEFs),3 and GTPase-activating proteins (GAPs). GDIs sequester Rho proteins away from their targets, while GEFs and GAPs respectively up- and down-regulate the cycle between ...
其在激活和失活状态间的转换主要由以下几类蛋白调控:GTP酶激活蛋白(GTPase-activating proteins,GAPs)、鸟嘌呤核苷酸转换因子(guanine nucleotide-exchange factors,GEFs)和鸟嘌呤核苷酸分离抑制因子(guanine nucleotide-dissociation inhibitors,GDIs)。GAPs主要增强内源性GTP酶的活性,GEFs主要催化GDP结合态到GTP结合态的转换...
RICH, a Rho GTPase-activating Protein Domain-containing Protein Involved in Signaling by Cdc42 and Rac1 A previously unidentified Rho GTPase-activating protein (GAP) domain-containing protein was found in a yeast two-hybrid screen for cDNAs encoding proteins ... N Richnau,Pontus Aspenstrm - 《...
The Rho GTPase-activating proteins (RhoGAPs) are one of the major classes of regulators of Rho GTPases found in all eukaryotes that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions. Recent studies have implicated them as specific ...