Experimental rhinovirus challenges in adults with mild asthma: response to infection in relation to IgE. J. Allergy Clin. Immunol. 111, 1008-1016. doi: 10.1067/mai.2003.1396Zambrano JC, Carper HT, Rakes GP, Patrie J, Murphy DD, et al. (2003) Experimental rhinovirus challenges in adults ...
[3, 4] In adults, evidence has shown that zinc decreases the duration of symptoms and severity. Antibacterial agents are not effective unless bacterial superinfection occurs. No antiviral agents are available to treat infections. Development of a vaccine is nearly impossible, because of the large ...
In adults, oral zinc reduced duration of illness when high doses (at least 75 mg of elemental zinc per day) were used and when taken within 24 hours of onset of common cold symptoms. This was not seen in children. Zinc has been associated with faster resolution of nasal congestion, nasal...
Natural rhinovirus infection in adults is usually associated with an afebrile coryzal syndrome (Hobson and Schild, 1960 ; Hamre and Procknow, 1961 ; Reilly et al., 1962 ; Forsyth et al., 1963), and, depending on the population studied, rhino viruses as a group are associated with 8 to...
Recent work has suggested that HRV-C may be more pathogenic in children with asthma than other HRVs (Bizzintino et al., 2011; Piralla et al., 2009) however its impact may not be so pronounced in adults (Wark, Tooze, Powell, & Parsons, 2013). In addition, AE-asthma have been ...
Human rhinoviruses (HRV), discovered in the 1950s, are ubiquitous respiratory viruses, which are mostly implicated in common cold and account for at least 50% of upper respiratory tract infections (URTIs) in children and adults. Rhinovirus infections occur all year round globally, with seasonalit...
Species include RV-A (adults > children), RV-B (least common) and RV-C (new species, often more severe or disseminated in children) Rhinoviruses gain entry via the upper respiratory tract, binding to ICAM-1 (intracellular adhesion molecule -1) receptors on epithelial cells lining the respira...
In older children and adults, HRV infections generally cause relatively mild respiratory illnesses and yet contribute to acute and potentially severe exacerbations in patients with asthma. These findings underline the importance of understanding the synergistic nature of allergic sensitization and infections ...
The only certainties in life are death and taxes—and the common cold. In fact, adults can expect to experience two or three colds every single year.1Many pathogens can cause cold symptoms. But the most frequent culprit are human rhinoviruses.2 ...
The first Phase 1 trial of an attenuated polio-rhinovirus chimera, PV (Sabin)-Rhinovirus IRES PV Open reading frame (PVSRIPO) was in 61 adults with recurrent glioblastoma who received a dose between 107 and 1010 median tissue culture infectious dose (TCID50) infused via intratumoral convection-...