Rhinoviruses are the aetiological agents of the most common acute infectious disease in humans, the common cold [1]. In the last few decades, several studies have provided clear evidence for a major role of respiratory viruses in triggering exacerbations of obstructive lung diseases [2], and ...
in precipitating severe respiratory disease syndromes such as acute exacerbations of asthma. Rhinoviruses belong to the familyPicornaviridae.Over 100 serotypes of HRV have been identified, thwarting efforts to date to develop an anti-HRV vaccine. Viral replication occurs in the cytoplasm and the ...
Limited data is available from Latin America regarding the clinical presentation and strains of these viruses in respiratory disease. We collected nasopharyngeal swabs at clinics located in eight Latin American countries from 3,375 subjects aged 25 years or younger who presented with influenza-like ...
It is thought that spores are released into the environment, where they contact susceptible human and animal hosts. Spores may be introduced into tissues after trauma to the mucous membranes, where they form sporangia that produce new spores. Because this disease in humans also occurs in arid re...
- 《Pediatric Infectious Disease Journal》 被引量: 153发表: 2009年 Human Rhinoviruses Human rhinoviruses (HRVs), first discovered in the 1950s, are responsible for more than one-half of cold-like illnesses and cost billions of dollars annual... S.,E.,Jacobs,... - 《Clinical Microbiology...
Rhinoviruses are the most common causes of viral respiratory infections and complications caused by viral respiratory infections in patients with underlying lung disease. Major recent therapeutic advances include the development of capsid-function inhibitors (pleconaril), inhibitors of 3C protease (AG7088)...
Picornaviruses are associated with serious diseases in humans and other animals, and they comprise one of the largest families of viral pathogens. For example, the common cold, poliomyelitis, foot-and-mouth disease and hepatitis can be caused by these viruses. They are among the smallest RNA-cont...
Rhinovirus (RV) is responsible for the majority of common colds and triggers exacerbations of asthma and chronic obstructive lung disease. We have shown that RV serotype 39 (RV39) infection activates phosphatidylinositol 3 (PI 3)-kinase and the serine threonine kinase Akt minutes after infection ...
Eight families with a rhinovirus-positive index child and 16 families with a rhinovirus-negative index child were monitored for 3 weeks for disease symptoms, and the presence and quantity of rhinoviruses in nasal swab samples were determined by quantitative reverse transcription-polymerase chain ...
Human rhinovirus (HRV) infections are major contributors to the healthcare burden associated with acute exacerbations of chronic airway disease, such as chronic obstructive pulmonary disease and asthma. Cellular responses to HRV are mediated through pattern recognition receptors that may in part signal ...