In a double blind placebo controlled study we have examined the effects of a single sc injection of rhIGF-1 (40ug/kg) on total IGF-I, IGF-BP1, IGF-BP3 and GH concentrations in 9 adolescents with IDDM (aged 14-18y, Tanner Stage 4 or 5, HbA1 range 7.1-17X). RhIGF-I or ...
pulmonary vascular density and pulmonary compliance, as well as inhibited EMT in airway epithelial cells in LPS and hyperoxia treated mice.ConclusionPostnatal rhIGF-1/BP3 treatment relieved the effects of LPS or hyperoxia on lung injury and prevented RVH, providing a promising strategy for the treat...
ANABOLIC EFFECTS OF ADMINISTRATION OF RECOMBINANT HUMAN IGF-1/BINDING PROTEIN 3 (rhIGF-1/BP3) ON PROTEIN METABOLISM IN ADULT BURN PATIENTSDebRoyZhang, X-JWolf, SEWolfe, RRHerndonJournal of Trauma and Acute Care Surgery
ANABOLIC EFFECTS OF ADMINISTRATION OF RECOMBINANT HUMAN IGF-1/BINDING PROTEIN 3 (rhIGF-1/BP3) ON PROTEIN METABOLISM IN ADULT BURN PATIENTSAn abstract is unavailable.doi:10.1097/00005373-199807000-00095X-J ZhangSE WolfRR WolfeJournal of Trauma Injury Infection & Critical Care...
Combination Recombinant Human Insulin-Like Growth Factor 1 (rhIGF-1) and IGF binding Protein 3 (BP)[SomatoKine] reduces Insulin Requirements and improves Glycemic Control in Type 1 Diabetes (DM)ALAN C. MOSESANDREAS SOMMERMCKAY MALCOLMROSEN DAVID...
THE EFFECTS OF rhIGF-1 ON GH,IEF-BP3 BND IGF-BP1 CONCENTRHTIONS BND INSULIN SENSITIVITY IN ADOLESCENTS UITH INSULIN DEPENDENT DIABETES MELLITUS (IDDW)THE EFFECTS OF rhIGF-1 ON GH,IEF-BP3 BND IGF-BP1 CONCENTRHTIONS BND INSULIN SENSITIVITY IN ADOLESCENTS UITH INSULIN DEPENDENT DIABETES MELLIT...
The principal BP, IGFBP-3, which binds 75% to 90% of circulating IGF-I, is a large ternary complex consisting of IGFBP-3, acid labile subunit (ALS), and IGF molecules. ALS and IGFBP-3 are produced in the Ever as a direct effect of GH. The ALS stabilizes the IGF-IGFBP-3 complex,...
Further, pharmacological studies of a IGF-I compound containing a 1:1 molar complex of rhIGF-I and rhIGF-binding protein-3 (BP-3) demonstrated that the complex was effective in increasing levels of circulating total and free IGF-I and that the administration in patients with GHIS should be...