Rheumatoid factor (RF) was determined using Quantex RF(II) (Biokit, Spain). Results Acceptable qualitative (96.6%, kappa = 0.93) and quantitative agreements (Spearman rho = 0.77; p < 0.0001) were observed between the two ACPA assays. Nine samples were CCP3 +/CCP2 and one sample was ...
Activation of endothelium and immune cells is fundamental to the initiation of autoimmune diseases such as rheumatoid arthritis (RA), and it results in trans-endothelial cell migration and synovial fibroblast proliferation, leading to joint destruction. In RA, the synovial microvasculature is highly dysr...
Results Univariate quality control Subjects and patients: sex discrepancies were discovered in 19 subjects, 2 subjects had a missing value rate above 5%, and 5 subjects were found to be related: these subjects were removed from the analysis. A total of 26 subjects, predominantly RA patients, wer...
the primary endpoints of superiority were not met. The post hoc analysis assessed the efficacy of certolizumab pegol, a PEGylated fragment crystalized (Fc)-free tumor necrosis factor inhibitor (TNFi) and adalimumab, an Fc-containing TNFi in p...
Results 9 patients were male and 62 female with mean age and duration of disease of 53.45 (±10.7) and 9.9 (±8.6), respectively. RF was positive in 52 (76%), ACPAs in 54 (76.1%) and ANA in 12 (16.9%). Thirty-six patients (50.7%) had systemic hypertension, 9 (12.68%) diabetes...
(CsA), blocked the effects of CBD (Fig.1k). Since RealTime-Glo assays were conducted at 37 °C in serum-free medium but without CO2and humidity control, we also confirmed these results in cell titer blue endpoint assays (Fig.5d). In vivo, CBD is bound to lipoproteins/albumin ...
Normalization was performed using the NormalizeData function, with “LogNormalise” as the normalization method and 10,000 as the scaling factor. To identify the most variable genes, the FindVariableFeatures function was applied with mean.var.plot (mvp) as a selection method, and the rest of ...
(1992) The small GTP- binding protein rac regulates growth factor- induced membrane ruffling. Cell. 70:401–10. 34. Small JV, Stradal T, Vignal E, Rottner K. (2002) The lamellipodium: where motility begins. Trends Cell Biol. 12:112–20. 35. Han Z, Boyle DL, Manning AM, Firestein...
All of the networks were optimized using an adaptive moment estimation (ADAM) optimizer33 in a batch size of 64 with an initial learning rate of 0.0003, which then decayed every 15 epochs, with a decay factor of 0.3. To address the class imbalance issue, training images were randomly ...
In vivo hypoxia PET imaging quantifies the severity of arthritic joint inflammation in line with overexpression of hypoxia-inducible factor and enhanced reactive oxygen species generation J Nucl Med, 58 (2017), pp. 853-860 CrossrefView in ScopusGoogle Scholar [88] P.C. Taylor, B. Sivakumar ...