Rheumatoid arthritisPatients with rheumatoid arthritis (RA) develop features of accelerated ageing, including immunosenescence. These changes include decreased thymic functionality, expansion of late-differentiated effector T cells, increased telomeric attrition, and excessive production of cytokines (senescence-...
The purpose of this review is to outline considerations for treating older adults with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) a
Rheumatoid arthritis (RA) is a systemic autoimmune disease that predominantly affects the joints. The prevalence of RA varies globally, with generally a higher prevalence in industrialized countries, which may be explained by exposures to environmental r
The risk of sarcopenia is high (with a prevalence of ≥25%) in individuals with rheumatoid arthritis (RA), and this rheumatoid sarcopenia is associated with increased likelihood of falls, fractures and physical disability, in addition to the burden of joint inflammation and damage. Chronic ...
Ageing, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity – catalysts of autoimmunity and chronic inflammation Rheumatoid arthritis (RA), like many other autoimmune syndromes, is a disease of adults, with the highest incidence rates reported in the elderly....
Rheumatoid arthritis: a role for im- munosenescence? J Am Geriatr Soc 2010;58:1565-1575... TM Lindstrom,WH Robinson,W Phd 被引量: 5发表: 2014年 Mitochondria, immunosenescence and inflammaging: a role for mitokines? A global reshaping of the immune responses occurs with ageing, indicated as...
Background Advancing age is recognised as a major risk factor for autoimmune inflammatory conditions, such as Rheumatoid Arthritis (RA). Despite strong associations with older age we understand little of the role ageing processes play in disease pathogenesis in RA. The immune system undergoes a ...
The market for rheumatoid arthritis treatment is being driven by a rise in the prevalence of arthritis and related joint issues. An unhealthy lifestyle, increasing metabolic disorders, ageing, a family history of joint ailments, and growing obesity are all contributing factors to the rise in rheuma...
This article summarizes the different aspects of rheumatoid arthritis and the spectrum of diseases that can present as rheumatoid arthritis in the elderly population. With the ageing of the western population, different forms of inflammatory arthritis' prevalence and incidence are increasing in elderly pe...
Rheumatoid arthritis (RA) develops through three stages: priming, onset, and chronicity [1]. In the priming stage, immune cells are activated, resulting in the production of disease-specific autoantibodies which can be detected in the blood several years before signs of clinical symptoms [2,3,...