RA引起的胞内信号通路改变——流式磷酸化 Phosflow 5:空间多组学 案例:DSP空间多组学技术助力类风湿关节炎治疗响应差异的分子机制解析 研究人员利用GeoMx® DSP空间转录组技术精细解析了类风湿关节炎(Rheumatoid Arthritis,RA),尤其是难治性类风湿关节炎(Refractory RA)患者滑膜样本中不同区域的基因表达谱差异。揭示了...
Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet. The inflammatory process is characterized by infiltration of inflammatory cells into the joints, leading to pr...
17.Tsushima H, Okazaki K, Ishihara K, et al. CCAAT/enhancer-binding protein β promotes receptor activator of nuclear factor-kappa-B ligand (RANKL) expression and osteoclast formation in the synovium in rheumatoid arthritis[J]. Arthritis Res Ther, 2015, 17(1): 31. DOI: 10.1186/s13075-015...
Folate and methotrexate (MTX) in rheumatoid arthritis (RA),Associate Professor Lisa Stamp,Interventional,Phase 4
使用R软件进行差异基因的筛选,并对这些差异基因进行基因本体论(GO)及基因通路富集(KEGG)富集分析。进一步利用SVM-RFE算法、LASSO回归和Random Forest算法等三种机器学习算法筛选诊断基因,同时进行外部验证和受试者工作曲线(ROC)分析,最后通过xCell算法计算免疫细胞在RA中的浸润情况。结果:筛选出RA差异基因共计704个。富集...
结论RA患者SFNK-22细胞体外可分泌高浓度的IL-22,通过激活STAT3信号通路进而刺激 RAFLS增殖。 关键词:类风湿关节炎;NK-22细胞;IL-22;STAT3 Abstract:ObjectiveToinvestigatetheroleofnaturalkiller-22(NK-22)cellsinthesynovialfluidintheproliferationof fibroblast-likesynoviocytes(FLS)inpatientswithrheumatoidarthritis(RA...
ranklopg在类风湿关节炎患者血清及t淋巴细胞上的表达及临床意义-expression and clinical significance of rank lopg in serum and t lymphocytes of rheumatoid arthritis patients.docx,2.5.8流式检测………182.5.9ELISA法检测………
Double filtration plasmapheresis for the treatment of rheumatiod arthritis: a study of 21 cases[J].Artif Organs, 1997, 21(2):96-98. 4 王金铠, 张金巧, 孟建波, 等.血浆置换疗法治疗547例自身免疫性疾病临床研究及疗效分析[J].临床荟萃, 2007, 22(9):670-671. 5 张学武, 任丽敏, 安媛, 等...
由欧洲药品管理局(EMA)发布的关于Concept paper on the need for revision of the points to consider on the clinical investigation of medicinal products other than nsaids in rheumatoid arthritis(关于修订类风湿性关节炎非甾体抗炎药类药物临床研究需要考虑的要点
RA引起的胞内信号通路改变——流式磷酸化 Phosflow 5:空间多组学 案例:DSP空间多组学技术助力类风湿关节炎治疗响应差异的分子机制解析 △点击放大图片 研究人员利用GeoMx® DSP空间转录组技术精细解析了类风湿关节炎(Rheumatoid Arthritis,RA),尤其是难治性类风湿关节炎(Refractory RA)患者滑膜样本中不同区域的基因表...