Harriet SaleMichael MosleyGraham RickettPat DorrRoy MansfieldMark HolbrookesBiochemical PharmacologyNapier C, Sale H, Mosley M, Rickett G, Dorr P, et al. (2005) Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. Biochem Pharm 71:...
The aim of this study was to determine if macaque represents a suitable species for the pre-clinical evaluation of novel CCR5 antagonists, such as maraviroc (UK-427,857), To do this we cloned and expressed CCR5 from rhesus macaque and compared the binding properties of [~(125)I]-MIP-1...