This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway...
12. Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cellsCancer Lett. 2015 PMID: 26319900 13. Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiencyJ Appl Physiol. 2014 ...
GTP-Binding Protein Rheb (RHEB) is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region.Highest levels of RHEB can be found in the skeletal and cardiac muscle, and it is vital in the regulation...
Biochemical and functional characteriza- tions of small GTPase Rheb and TSC2 GAP activity[J]. Mol Cell Biol, 2004, 24 :7965-7975.Li Y, Inoki K, Guan KL (2004) Biochemical and functional char- acterizations of small GTPase Rheb and TSC2 GAP activity. Mol Cell Biol 24: 7965-7975...
由小GTP结合和水解蛋白(small GTP binding and hydrolyzing proteins ,GTPases)组成的Ras超家族,作为双向分子开关调节信号转导过程。Ras活性受两类蛋白的控制:GTPases 激活蛋白(GTPase activating proteins,GAPs)促进GTP-bound水解为GDP,抑制Ras;鸟苷酸交换因子(guanine nucleotide exchange factors,GEFs),催化GDP-bound...
Small GTPases are a super-family of cellular signaling regulators. RheB is a member of the Ras-superfamily GTPases. RheB has been shown to interact with C-Raf, Mammalian target of rapamycin (mTOR), TSC2, Ataxia telangiectasia mutated (ATM), KIAA1303 and Ataxia telangiectasia and Rad3 relat...
Gene encoding for GTP-binding protein Rheb. RHEB is a member of thesmall GTPasesuperfamily and encodes a lipid-anchored, cellmembrane proteinwith five repeats of the RAS-related GTP-binding region. This protein is vital to the regulation of growth andcell cycle progressiondue to its role in th...
描述 GTP-Binding Protein Rheb (RHEB) is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. Highest levels of RHEB can be found in the skeletal and cardiac muscle, and it is vital in the reg...
GTP-Binding Protein Rheb (RHEB) is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region.Highest levels of RHEB can be found in the skeletal and cardiac muscle, and it is vital in the regulation...
Gene Summary This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K sig...