Attempts to optimize the reductive cyclization of borylated 1,6-enynes to yield a single product were not successful; in addition, the distribution of products in these reactions was poorly reproducible. On the
The design or discovery of new reactions can be stimulated through the acyloxy migration and the subsequent reactions; oxidative addition, migratory insertion, and reductive elimination. Section snippets Methodology Quantum mechanical calculations were performed with Density Functional Theory (DFT). Geometry ...
In the case of alkene-tethered 1,6-allenyne, both 1,2- and 2,1-insertions of alkene into the Rh-C(sp(2)) bond of the five-membered rhodacyclic intermediate are plausible, and the resulting rhodium-alkyl intermediates will afford cycloisomerization products through reductive elimination. In ...
(sp2)−H insertion with cationic Rh(III) complexes to furnish five-member metallacycles, which could further be converted into 2,3-dihydropyridine products in good yields via an irreversible migratory insertion and reductive elimination under the presence of 1,1-disubstituted olefins (Scheme 17)...