RGS (regulator of G protein signaling) proteins containing the G protein γ-like (GGL) domain (RGS6, RGS7, RGS9, and RGS11) interact with the fifth member of the G protein β-subunit family, Gβ5. This interaction is necessary for the stability of both the RGS protein and for Gβ5...
Instability of GGL domain-containing RGS proteins in mice lacking the G protein β-subunit Gβ5.RGS (regulator of G protein signaling) proteins containing the G protein γ-like (GGL) domain (RGS6, RGS7, RGS9, and RGS11) interact with the fifth member of the G protein β-subunit family...
Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets 2012, Blood Citation Excerpt : Thirty-seven RGS domain–containing proteins have been identified in humans,5 and in a recent transcriptome analysis, at least 16 were shown to be expressed in human platelet...
Robust effects by all three members of the regulator of G-protein signaling (RGS) domain containing RhoGEFs (ArhGEF1, ArhGEF11 and ArhGEF12) prompted studies relating their known roles in serum signaling onto the regulation of Yap1. Under all conditions examined, ArhGEF12 preferentially ...
However, p115RhoGEF is a GTPase Activating Protein (GAP) toward Gα13,... Zhe,Chen,William,... - 《Structure》 被引量: 56发表: 2008年 Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain. RGS-containing RhoGEFs (RGS-RhoGEFs) represent a direct...
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2.1 Gene and protein organization RGS10 is a small RGS protein that resembles the structure of R4 subfamily members. However, based on RGS domain sequence similarity, RGS10 is classified as a third member of the D/R12 subfamily which also includes the proteins RGS12 and RGS14 (Fig. 3A) [...
Co-expression of G beta 5 enhances the function of two G gamma subunit-like domain-containing regulators of G protein signaling proteins Regulators of G protein signaling (RGS) stimulate the GTPase activity of G protein G alpha subunits and probably play additional roles. Some RGS proteins c.....
p115RhoGEF, a guanine nucleotide exchange factor (GEF) for Rho GTPase, is also a GTPase-activating protein (GAP) for G12 and G13 heterotrimeric Gα subunits. The GAP function of p115RhoGEF resides within the N-terminal region of p115RhoGEF (the rgRGS domain), which includes a module ...
Hedgehog (Hh) signaling plays fundamental roles in morphogenesis, tissue repair, and human disease. Initiation of Hh signaling is controlled by the interaction of two multipass membrane proteins, patched (Ptc) and smoothened (Smo). Recent studies identif