Sign in to download full-size image Figure 14.1. Schematic representation of the CendR transport pathway [4]. The process of tumor penetration with TPPs: (1) binding with a primary receptor on tumor endothelial cells; (2) peptide cleavage by protease to expose the CendR motif; and (3) bind...
thereby preserving the function and biological activity of the peptides. This conjugation also enhances the cycling stability and targeting of drugs in vivo while reducing their toxic side effects. The mechanism of action of PDCs is similar to that of antibody–drug conjugates (...
On the other hand, short linear peptides, mimicking the RGD sequence showed a significantly lower binding to αIIbβ3 , and had limited effect on platelet functions5. A few years later, we addressed the need of focusing on high affinity ligands toward αvβ3 while maintaining...
The RGD-4C peptide (ACDCRGDCFCG) contains four cysteine residues. Previously, Majhen et al. were specifically interested in how many intramolecular disulfide bonds and in which configuration were formed within the RGD4C peptide inserted in the HI loop of the fiber knob domain, and whether the d...
Diverse alpha and beta subunits are engaged to form 24 distinct integrin transmembrane heterodimers recognizing RGD peptide motifs, laminin receptors, collagen receptors, and leukocyte-specific integrins [45]. Since the binding of the identical ligands to diverse integrin receptors causes distinct responses...
Following this approach, RGD-containing peptides have been successfully conjugated with diverse anticancer drugs, as doxorubicin, doxsaliform, monomethylauristatin E, cisplatin, camptothecin and paclitaxel15,16. An important issue is also the increase in water solubility of the drug due to peptide or...
Carrier peptides can deliver other components of cosmetic preparations when these are applied topically. In this study, we explored the possibility of synthesis of a phytochemical (gallic acid) and a peptide for use as a cosmetic ingredient. We assessed 3 aspects of the novel compound (galloyl-...
Figure 1Molecular model and schematic illustration of the functionalized peptide scaffold RAD/PRG/KLT. (A) Amino acid sequences and molecular models of RAD, PRG and KLT. (B) Proposed molecular models for RAD/PRG and RAD/KLT. (C) Schematic illustration of the RAD/PRG/KLT hydrogel. (D) The...
Since neovas- cular vessels are abundant in tumors, and αvβ3 integrin is highly expressed in cancer, we used the RGD peptide as a target moiety in our study.23,38 In this study, we prepared a novel LCP-RGD targeted nanoparticle, which can effectively encapsulate and then slowly release ...
J. Peptide Protein Res. (1992) 40, 171–1791, By circular dichroic spectroscopy, each of these five RAMPs contained an α-helical coiled coil. The disulfide-bridged dimer RGD-A23a/RGD-A23a and its reduced form (RGD-A23a)2 had two N-terminal RGD sites. The disulfide-bridged dimer A9a...