Rewiring the Addicted Brain: Circuits-Based Treatment for Addiction.doi:10.1101/SQB.2018.83.038158Graziella MadeoAntonello BonciCold Spring Harbor Laboratory Press
This scarcity brain is responsible for humans making it as far as we have so far, but it's also maladaptive for modern times. We eat too much, we hoard possessions, we get sucked into our devices and social media, we get addicted to drugs, we get addicted to gambling, status, even ...
The mortality rate of epithelial ovarian cancer (EOC) remains the first in malignant tumors of the female reproductive system. The characteristics of rapid proliferation, extensive implanted metastasis, and treatment resistance of cancer cells require an
14,15,16. Thus, this cell line pair offers the opportunity to compare the EGFR PPIN in cells expressing a transforming vs. a non-transforming dosage of mtKRAS. Furthermore, HCT116 are not addicted to mtKRAS for survival, minimizing selection pressure...
Drug-induced plasticity, or "rewiring" of the braincontributes to the development, maintenance, and persistence of the addicted state (Kalivas and O'Brien,2008). The goal of this Research Topic is to assimilate recent findings related to plasticity and structuralalterations produced by drug of ...
BMAL Brain and Muscle ARNT-Like PER2 Period Circadian Regulator 2 GCN5 General control of amino acid synthesis 5 MFN-1 Mitofusin 1 MFN-2 Mitofusin 2 FAK Focal Adhesion Kinase Drp1 Dynamin-1-like Protein GSK-5b Glycogen Synthase Kinase 5 Beta SOD2 Superoxide Dismutase 2 MMP2 Matrix Metallopept...