The article reports on the result of the study which assesses the role of brain reward circuits in the development of obesity and addiction in rat models conducted by the U.S. National institute on Drug Abuse (NIDA). The study evaluated the response of the reward circuits when the rats ...
particularly in a region of the brain called thenucleus accumbens. Located near the center of the brain, the nucleus accumbens is connected, by intermingled populations of cells, to many other brain structures having roles in pleasure seeking anddrug addiction. The nucleus accumbens...
New treatments for addiction could result from studies of ibogaine, an alkaloid derived from a West African shrub. Animal tests and anecdotal evidence in humans have indicated that ibogaine reduces cravings for alcohol and other drugs of abuse. Now, researchers at the University of California, San...
Anxiety; Depression Affective Influences on Decision Making in Adolescents Ronald E Dahl*, Jennifer Lerner, Ahmad R Hariri, Cecile Ladouceur, Cameron Carter and Neal D Ryan Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA Background: Most measures of cognitive abilities ...
Based on brain imaging findings, we present a model according to which addiction emerges as an imbalance in the information processing and integration among various brain circuits and functions. The dysfunctions reflect (a) decreased sensitivity of reward circuits, (b) enhanced sensitivity of memory ...
Advances in neuroscience identified addiction as a chronic brain disease with strong genetic, neurodevelopmental, and sociocultural components. We here discuss the circuit- and cell-level mechanisms of this condition and its co-option of pathways regulating reward, self-control, and affect. Drugs of ...
The pleasure you feel from every shopping victory is real. Shopping, like any new or exciting experience, activates thebrain’s reward center, triggering the release of dopamine. 译:每次购物满载而归时,我们感到的快乐都是真真切切的。与其他刺激...
A widely accepted assumption in addiction research is that overvaluation of drug cues is caused by enhanced dopaminergic response to these cues. Here, the authors show similar dopamine neuronal responses to cues predicting opioids vs. natural rewards. ...
The Salted Food Addiction Hypothesis may explain overeating and the obesity epidemic the brain's reward and pleasure center more than it is "tasty", while salted food preference, urge, craving and hunger may be manifestations of opiate... JA Cocores,MS Gold - 《Medical Hypotheses》 被引量: ...
GABAergic cells that project broadly to the nucleus accumbens, but projections only to a specific portion contribute to reward reinforcement,” said co-lead author Raajaram Gowrishankar, a postdoctoral scholar in the Bruchas Lab and the Center for the Neurobiology of Addiction, Pain, and Emotion....