NeurotoxicityOxidative stressApoptosisMitochondrial damageT-2 toxin is a representative trichothecene that is widely detected in corn, wheat and other grain feeds. T-2 toxin has stable physical and chemical properties, making it difficult to remove from food and feed. Hence, T-2 toxin has become ...
Neurofilaments (NF) are the most abundant cytoskeletal component of large myelinated axons from adult central and peripheral nervous system. Here, we provide an overview of the complementary approaches, including biochemistry, cell biology and transgenic technology that were used to investigate the asse...
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mitochondrial dysfunction and environmental toxicant exposures DA Rossignol1 and RE Frye2 1International Child Development Resource Center, Melbourne, FL, USA and 2Arkansas Children's Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA Recent studies have implica...
T. Cunha-Oliveira, A.C. Rego, C.R. Oliveira Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs Brain Res. Rev., 58 (1) (2008), pp. 192-208 View PDFView articleView in ScopusGoogle Scholar da Cruz et al., 2022 L.L. da Cruz, G. Ve...
In the contexts of aging, injury, or neuroinflammation, activated microglia signaling with TNF-α, IL-1α, and C1q induces a neurotoxic astrocytic phenotype, classified as A1, A1-like, or neuroinflammatory reactive astrocytes. In contrast to typical astr
期刊名称:《Annual Review of Medicine》 | 2021年第1期 关键词: chimeric antigen receptor; T cells; adoptive cell therapy; toxicity; cytokine release syndrome; neurotoxicity; ICANS; tocilizumab; 19.Biological Aspects of Cancer Health Disparities 机译:癌症健康差异的生物方面 作者:Freedman Jennifer A...
(1998) examined the repeat dose sub-chronic toxicity and neurotoxicity of TEGME in male and female rats. In this study, male and female rats were exposed for 90 days under occlusive conditions to dermal doses of 400, 1200 and 4000 mg/kgbw/d. No statistically or biologically significant, ...
Apoptosis associated speck like protein containing CARD (ASC) is widely researched and recognized as an adaptor protein participating in inflammasome assem
The discovery that melanized neurons of thepars compacta of substantia nigra (pcSN) degenerate in the midbrain of human Parkinsonians is nearly a century o