NeurotoxicityOxidative stressApoptosisMitochondrial damageT-2 toxin is a representative trichothecene that is widely detected in corn, wheat and other grain feeds. T-2 toxin has stable physical and chemical properties, making it difficult to remove from food and feed. Hence, T-2 toxin has become...
Neurotoxicity is not the only detrimental effect of protein aggregation in the context of neurodegenerative disease. Reactive responses may also be induced by the loss of function that accompanies the sequestration of proteins important for normal cellular function. TDP-43 inclusions within neurons and ...
Mycotoxins are secondary metabolites of different species of fungi.Aflatoxin B1(AFB1),deoxynivalenol(DON),zearalenone(ZEN)and fumonisin B1(FB1)are the main mycotoxins contaminating animal feedstuffs.These mycotoxins can primarily induce hepatotoxicity,immunotoxicity,neurotoxicity and nephrotoxicity,consequently cau...
The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides. Philos Trans R Soc Lond B Biol Sci 360: 2309–2314, 2005. 3. Abramov AY, Scorziello A, and Duchen MR. Three distinct mechanisms generate oxygen free radicals in neurons and con- tribute to cell death...
(1998) examined the repeat dose sub-chronic toxicity and neurotoxicity of TEGME in male and female rats. In this study, male and female rats were exposed for 90 days under occlusive conditions to dermal doses of 400, 1200 and 4000 mg/kgbw/d. No statistically or biologically significant, ...
Activation and catalytic properties of ureases Ureases inhibitors Biological roles of ureases that require ureolytic activity Biological properties of ureases independent of ureolysis Neurotoxicity of ureases Contributions of ureases to plant defense against predators and pathogens Structural aspects of jabu...
Although the involvement of genetic abnormalities in autism spectrum disorders (ASD) is well-accepted, recent studies point to an equal contribution by environmental factors, particularly environmental toxicants. However, these toxicant-related studies i
Relative importance of proteinase-activated receptor-1 versus matrix metalloproteinases in intracerebral hemorrhage-mediated neurotoxicity in mice. Stroke 2009; 40: 2199–204. 53 Guangzhou University of Traditional Chinese Medicine. Clinical re- evaluation of removing blood stasis therapy in treating acute ...
postulates that CNS demyelination occurs as a possible result of direct neurotoxicity of a neurotropic virus, and that vaccination with an attenuated virus strain may cause problems only if administered during a preceding infection, in which previously primed virus-specific cytotoxic T cells are ...
1. Overview of genus Lachesis 2. Lachesis envenoming: epidemiology, symptoms and treatment 3. Bioactive components of Lachesis venom 4. Concluding remarks and perspectives Credit author statement Ethical statement Funding Declaration of competing interest Acknowledgements References Cited by (9) Figures ...