Hypertension progresses rapidly when associated with chronic kidney disease (CKD) to become treatment‐resistant. Renal denervation (RDN) is reportedly effective in lowering blood pressure in this disease but the pathophysiological mechanisms are not fully investigated. A rabbit model of moderate CKD, ...
Close to 9% of the Mexican population has chronic kidney disease (CKD) and 40... GG Guillermo,RL Karina,MM Isela - 《Seminars in Nephrology》 被引量: 92发表: 2010年 Difference in rate of uptake of immunization among ethnic groups In the Bradford health district ethnic origin is associated...
which is mainly expressed in kidney tubular epithelium, choroid plexus in the brain and secreted in the blood [15,16]. It regulates phosphate and calcium metabolism, resists oxidative stress, and down-regulates apoptosis, while exhibiting anti-inflammatory and anti-fibrotic functions [17]. Serum KL...
Pathophysiologic Implications and Therapeutic Approach of Klotho in Chronic Kidney Disease: A Systematic Review. Lab Invest. 2023;103: 100178. Article PubMed Google Scholar Shaid S, Brandts CH, Serve H, Dikic I. Ubiquitination and selective autophagy. Cell Death Differ. 2013;20:21–30. ...
• Too little AAT reaches the lungs, where it’s needed to rein in elastase, an enzyme produced by white blood cells. Elastase helps kill bacteria in the lungs, but uncontrolled elastase activity can damage lung tissue and lead to severe emphysema (chronic obstructive pulmonary disease). ...
drug store and currently do not require prescriptions from a doctor. Heart patients should be concerned with the correct dosage; exactly how much must be taken and for how long to resolve their chronic scurvy, i.e. their chronic vitamin C deficiency (also known as cardiovascular disease or ...
Mechanisms of disease: oxidative stress and inflammation in the pathogenesis of hypertension. Nat Clin Pract Nephrol 2006; 2: 582–593. 34 Vaziri ND. Causal link between oxidative stress, inflammation, and hypertension. Iran J Kidney Dis 2008; 2: 1–10. 35 Moreno JJ. Resveratrol modulates ...
1,2 The hallmarks of aging include cellular senescence, genomic instability, epigenetic alterations, loss of proteostasis, stem cell exhaustion, chronic inflammation, and altered intercellular communication.1,3 Of these, cellular senescence is a state of stable cell cycle arrest triggered by various ...
Treating and reversing elevated LVM may reduce the burden and progression of kidney disease in this high-risk population.doi:10.1053/j.ajkd.2016.11.022... LR Zelnick,R Katz,BA Young,... - 《American Journal of Kidney Diseases》 被引量: 2发表: 2017年 ...
MDSCs originate from immature myeloid progenitor cells (IMPs) in chronic pathological conditions like cancer and can suppress the function of T and natural killer cells that fight against tumors [9,10]. Therefore, current research aims to identify new immune checkpoint targets beyond PD-1 and ...