The G:C reverse Watson-Crick (W:W trans) base pair, also known as Levitt base pair in the context of tRNAs, is a structurally and functionally important base pair that contributes to tertiary interactions joining distant domains in functional RNA molecules and also participates in metabolite bind...
The silver DNA double helix represents the first example of a ps DNA structure built up of bidentate and tridentate reverse Watson-Crick base pairs stabilized by a dinuclear silver-mediated PyrdC pair.Yang, HaozheMei, HuiSeela, FrankChemistry: A European journal...
Interestingly, only the d(G,T) and d(G x C) base-pairs were observed in the heteroduplexes, suggesting that both the d(G x T) reverse wobble and d(G x C) reverse Watson-Crick base-pairs are more stable in this crystal environment than the d(G x G) reverse Hoogsteen base-pair...
The ternary structure RT, DNA, and (−)-3TC-TP (RT–DNA•(−)-3TC-TP) was also crystallized and solved (Fig.3b). Overall, the binding mode is very similar to the one in RT–DNA•(−)-FTC-TP (Fig.5a). There is a normal Watson–Crick base pair formed with the template...
For each strand, the cell contains a complementary strand, which provides a Watson-Crick pair for each nucleotide base. Adenine forms hydrogen bonds with thymine, and cytosine forms hydrogen bonds with guanine, so the complementary sequence for ACTG is TGAC. The two complementary strands with hydr...
In the mid-20th century there were many advances in molecular biology, including the description of DNA in 1953 by American geneticist and biophysicistJames D. Watsonand British biophysicistsFrancis CrickandMaurice Wilkins. By the 1960s it was understood that sarcomas are caused by amutationthat ...
Specific solvation effects on the struc- tures and properties of Watson-Crick and reverse Watson-Crick iso- cytosine-cytosine and guanine-cytosine base pairs: a theoretical ab initio study. J Mol Struct Theochem 1999;487:107-115.Zhanpeisov NU, Leszczynski J (1999) Specific solvation effects ...
PNA is the only example of a biopolymer whose backbone structure differs significantly from that of natural nucleic acids which nevertheless follows Watson-Crick base-pairing rules with complementary strands. Initially, PNAs were investigated as potential antisense compounds.Michael J. Lutz...
(1998). “Binding of the Modified Daunorubicin WP401 Adjacent to a T-G Base Pair Induces the Reverse Watson-Crick Conformation: Crystal Structures of the WP401-TGGCCG and WP401-CGG[ br5C] CG Complexes,” Nucleic Acids Res. 26(12):3001-3005. ;26(12):3001-3005....