REVERSAL OF DIGOXIN TOXICITY REVEALED IRREVERSIBLE AV NODAL DISEASEdoi:10.1016/S0735-1097(19)33389-3Nguyen, VyLau, KarriePerez, ViankaIskandar, MarcAlonso, RaulLopez, Hans RutzenElsevier ScienceJournal of the American College of Cardiology
Rates of reversal of advanced digoxin toxicity by digoxin-specific IgG and Fab fragments were therefore compared in a dog model of advanced digoxin intoxication. Initial studies confirmed more rapid distribution of sheep Fab fragments (M.W. 50,000) than of the parent IgG molecule (M.W. 150,...
The time course of the reversal of toxic and nontoxic effects of digoxin by digoxin-specific antibody fragments (Fab) was measured in isolated human ventricular myocardium. A concentration of 2脳10 6 mol/l digoxin was used to produce positive inotropy followed by mechanical signs of toxicity. ...
Digoxin is the substrate of Pgp and induces paclitaxel resistance by increasing Pgp [166]. Not only Pgp but also MRP and BCRP could affect the bioa- vailability of drugs. Page 3 of 13 (page number not for citation purposes) Cancer Cell International 2005, 5:30 http://www.cancerci.com...
generation chemosensitizers. The problems related with the first-generation chemosensitizers are that they generally show low effects and high toxicity at resistance-inhibiting doses. In order to supplement these problems, the chemosensitizers developed only for chemosensitizing effects are called the ...
To test further their efficacy in reversal of advanced, otherwise lethal digoxin toxicity and investigate the possible immunological adverse effects on patients in clinical practice, digoxin specific monoclonal antibody Fab fragments (dig-McAb) and IgGs were used to treat monkeys with threatening digoxin...
[Reversal of severe digoxin toxicity in guinea pigs using specific monoclonal antidigoxin antibody (McAb) and the inotropic effects of cardiac glycosides o... [Reversal of severe digoxin toxicity in guinea pigs using specific monoclonal antidigoxin antibody (McAb) and the inotropic effects of cardiac...
Digoxin immune Fab therapy was begun because of the fulminant psychiatric manifestations of this toxic state and the clear danger of self-inflicted physical harm. Within 3 h of therapy, a complete and spectacular resolution of all mental symptoms was observed. 展开 关键词: digitalis toxicity ...
generation chemosensitizers. The problems related with the first-generation chemosensitizers are that they generally show low effects and high toxicity at resistance-inhibiting doses. In order to supplement these problems, the chemosensitizers developed only for chemosensitizing effects are called the ...
Purified Fab fragments of digoxin-specific antibodies have recently been used clinically to reverse intractable hyperkalemia and advanced atrioventricular block following massive suicidal digoxin ingestion (Smith et al., 1976). Due to the high mortality rate associated with overwhelming digitoxin toxicity ...