Genome-wide functional screening using the CRISPR-Cas9 system is a powerful tool to uncover tumor-specific and common genetic dependencies across cancer cell lines. Current CRISPR-Cas9 knockout libraries, however, primarily target protein-coding genes. T
Like pancreatic cancer, esophageal cancer, which can begin anywhere in the muscular tube that runs from the throat to the stomach, has a low long-term survival rate. But unlike pancreatic cancer, research has produced insights into how to reduce the risk of developing esophageal cancer, including...
Human cancer cell lines have long served as tools for cancer research and drug discovery, but the presence and the source of intra-cell-line heterogeneity remain elusive. Here, we perform single-cell RNA-sequencing and ATAC-sequencing on 42 and 39 human
And second, basic research in cancer immunology paved the way for the development and approval of checkpoint blockers. These drugs, which augment T cell activity by blocking cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed cell death protein 1 (PD-1), or PD-1 ligand (PD-L1), show ...
CD8+ T cell-based cancer immunotherapy Yanxia Chen Dingning Yu Zhimin Tao Journal of Translational Medicine(2024) Advertisement Nature Immunology (Nat Immunol)ISSN1529-2916(online)ISSN1529-2908(print) Sign up for theNature Briefing: Cancernewsletter — what matters in cancer research, free to your...
Researchers at the Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, have developed nanosensors that target lung cancer proteins and can be delivered via inhaler or nebulizer, according to research published this month inScience Advances.If the sensors spot these proteins, t...
The clinical heterogeneity of early-stage endometrial cancer (EC) is worthy of further study to identify high-quality prognostic markers and their potential role in aggressive tumor behavior. Mutation of TP53 was considered as an important primary triage
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that can cause dementia. We aim to screen out the hub genes involved in AD based on microarray datasets. Gene expression profiles GSE5281 and GSE28146 were retrieved from Gene Expressio
Cell sorting for this project was done on instruments in the Stanford Shared FACS Facility, including an instrument purchased by the Parker Institute for Cancer Immunotherapy. This research was supported by an NIH Director’s New Innovator award (1DP2HD084069-01) to M.C.B., by the Ludwig ...