In mammals, generation of RA during early embryogenesis is a two-step metabolic process controlled primarily by tissue-specific expression of two enzymes: retinol dehydrogenase 10 (RDH10) and retinaldehyde dehydrogenase 2 (RALDH2). RA functions as a ligand for DNA-bound nuclear receptors that ...
Dermatology drugs Retinoic acid(Tretinoin,302-79-4) is commonly used in dermatology drugs, which is the department of vitamin A (Victoria methanol) metabolic intermediates.It mainly affects the growth of bones and epithelial metabolism, can promote epithelial cell proliferation and updates, and can ...
The dormant LT-HSCs divide slower, have a lower metabolic rate, and respond with a delayed repopulation/activation capacity when transplanted, although they possess the most potent capability to regenerate the hematopoietic system under stress conditions. However, it is unknown how, and at which ...
There is now a general consensus that RDH10 is the major enzyme involved in the synthesis of retinoic acid within the body (Kedishvili, 2013). RDH1 and Dhrs9 too are proposed by some investigators to have a physiologic role in this metabolic process (Kedishvili, 2013; Yang et al., 2017...
metabolicAlthough congenital scoliosis is defined as a genetic disease characterized by a congenital and abnormal curvature of the spinal vertebrae, our knowledge of the genetic underpinnings of the disease is insufficient. We herein show that the downregulation of the retinol-retinoic acid metabolism ...
metabolic process (e.g.,Sox4), stem cell division (e.g.,Zbtb16,Etv5), etc (Supplementary Fig.12a). Cluster 1 is enriched in genes involved in the regulation of gene silencing (e.g.,Hist1h1e), mitochondrial electron transport, NADH-ubiquinone (e.g.,Park7), retinoic acid and ...
They are key building blocks in all membranes and in the structures forming the outer layers of skin, and they undergo an active metabolic process that provides many compounds other than the important β-oxidation product, acetyl coenzyme A (CoA). This review focuses on the metabolism of these...
All-trans retinoic acid (ATRA) is the active form of the metabolite of vitamin A and produced from the metabolic conversion of retinol. The uterine endometrium is a retinoic acid accumulated tissue, and has been recognized as being necessary for normal endometrial cell differentiation and functions...
In vertebrates, the inner ear is comprised of the cochlea and vestibular system, which develop from the otic vesicle. This process is regulated via inductive interactions from surrounding tissues. Tbx1, the gene responsible for velo-cardio-facial syndrom
et al. A distinct metabolic state arises during the emergence of 2-cell-like cells. EMBO Rep. 21, e48354 (2020). Article CAS PubMed Google Scholar Tagliaferri, D. et al. Retinoic acid induces embryonic stem cells (ESCs) transition to 2 cell-like state through a coordinated expression ...