"This work has future implications to enhance outcomes of RPE cell therapy. For example, prior to transplantation, RPE cells in culture that display this distinct gene expression profile can be selectively chosen for RPE transplant to enhance post-transplant survival. Moving forward, we hope to dev...
affecting individuals of all ages. Cell-based therapy has emerged as an effective approach for the treatment of RDDs with promising results. This meta-analysis aims to comprehensively evaluate the efficacy of cell therapy in treating age-related macular degeneration (AMD), retinitis pigmentosa...
is increasing the need for effective therapies. Retinal gene therapy provides hope to people suffering from these hereditary illnesses by treating the underlying causes of visual loss. Gene therapy focuses on curing IRDs by repairing or compensating for the gene...
Follow-up of age-related macular degeneration patients treated by photodynamic therapy with optical coherence tomography 3 BACKGROUND: Photodynamic therapy (PDT) has been described to effectively reduce or delay severe vision loss in eyes with predominantly classic form of chor... J Montero,J Ruiz-...
A wide range of retinal disorders can potentially be treated using viral vector-mediated gene therapy. The most widely used vectors for ocular gene delivery are based on adeno-associated virus (AAV), because they elicit minimal immune responses and media
Interim safety and efficacy of gene therapy forRLBP1-associated retinal dystrophy: a phase 1/2 trial This phase I/II clinical trial was designed to assess safety and efficacy of gene therapy for Bothnia dystrophy, an inherited retinal degeneration leading to blindness. Kvantaet al. show interim...
Massachusetts General Hospital (MGH) researchers have used gene therapy to restore useful vision to mice with degeneration of the light-sensing retinal rods and cones, a common cause of human blindness. Their report, appearing in the Oct. 14 Proceedings
Even so, these findings may have significant implications for retinal gene therapy using adeno-associated viral (AAV) vectors since AAV transduction of RPE and Müller glia could lead to viral antigen presentation and clinically undesirable retinal immune cell infiltration38. Whether the retinal ...
Mesenchymal Stem Cells (MSCs) have been studied extensively for the treatment of several retinal diseases. The therapeutic potential of MSCs lies in its ab
AAV-Mediated Gene Therapy for Retinal Degeneration in therd10Mouse Containing a Recessive PDEβ Mutation To test AAV-mediated gene therapy in the rd10 mouse, a natural model of recessive RP caused by mutation of the beta-subunit of rod photoreceptor cGMP phosp... Ji-jing,Pang,Sanford,... ...