degenerationBackground ARSACS (autosomal鈥搑ecessive spastic ataxia of Charlevoix-Saguenay) is a neurodegenerative disorder caused by SACS gene mutations and characterized by a triad of symptoms: early-onset cer
This systematic study of the progression of retinal degeneration in distinct sheep models of CLN5 and CLN6 NCL has highlighted the differential vulnerability of retinal cell types in each disease and the time course of degeneration. In CLN5 sheep, the outer retina is most severely affected, with s...
Moreover, the protective effects of KUS121 in rd12 mice were confirmed even when the medication was started at 13 months of age, when the degeneration had progressed considerably, which approximates the situation in patients with advanced symptoms. In retinitis pigmentosa, ER stress has been ...
Other eye-related conditions may also increase the risk of ERDs. These includeage-related macular degeneration,Coats’ diseaseandretinal vein occlusion, among others. Symptoms may not be apparent in the early stages of an ERD. Diagnosing retinal detachment Retinal detachment diagnosis generally begins ...
Retinal diseasesare rather complex. They may have a genetic or multifactorial cause. Inheritedretinal degenerationsmay be sporadic, dominant, recessive, X-linked, maternal (mitochondrial), or digenic (Rivolta et al., 2002). In addition, they differ in onset, function of the gene product, pattern...
Retinitis pigmentosa is a group of hereditary retinal degenerations characterized by progressive dysfunction of the photoreceptors and associated with progressive cell loss and eventual atrophy of several retinal layers. The hallmark symptoms of retinitis pigmentosa are night blindness(nyctalopia) and graduall...
.This kind happens when fluid builds up behind your retina, but there’s no tear. The fluid pushes your retina away from the tissue behind it. Common causes include leaking blood vessels and swelling because of conditions such as an injury, inflammation, or age-related macular degeneration....
(a fatty yellow pigment) within the cells located beneath the macula, damaging cells critical for clear central vision. Additionally, this disease causes nocturnal visual impairment, and certain patients may experience compromised color vision. The manifestation of symptoms is commonly observed throughout...
Retinal degeneration RP: Retinitis pigmentosa RPC: Retinal progenitor cells RPE: Retinal pigment epithelium SC: Stem cells VSEL: Very small embryonic-like stem cells References MacLaren, R. E., Pearson, R. A., MacNeil, A., et al. (2006). Retinal repair by transplantation of photoreceptor prec...
Although these symptoms tended to fluctuate with time, having macular degeneration and problems with adaptation to vision loss were two of the risk factors identified for developing depressive symptoms (Heesterbeek et al., 2017). Therefore, vision loss and the associated sequelae have a significant ...