The protein consists of the reticulon-homology domain (RHD) that is flanked at the N- and C-termini by an intrinsically disordered protein region (IDPR), where the C terminal IDPR carries the indispensable LC3-interacting region (LIR) motif for the interaction with LC3. The RHD of RETREG...
FAM134B/RETREG1 is a selective ER-phagy receptor that regulates the size and shape of the endoplasmic reticulum. The structure of its reticulon-homology domain (RHD), an element shared with other ER-shaping proteins, and the mechanism of membrane shaping remain poorly understood. Using molecular...
The endoplasmic reticulum (ER) is shaped by a class of membrane proteins containing reticulon homology domain (RHD), the conserved hydrophobic domain encompassing two short hairpin transmembrane domains. RHD resides in the outer leaflet of the ER membran
Reticulons are integral ER membrane proteins characterised by a reticulon homology domain comprising four transmembrane domains which results in the proteins sitting in the membrane in a W-topology. Here we report on a novel subgroup of reticulons with an extended N-terminal domain and in particular...
RTNs share a 200-amino-acid residue region of sequence similarity at the C-terminus; the reticulon homology domain (RHD), which is responsible for the association to the ER membrane. This region is composed of two hydrophobic regions spaced by an ∼60-amino-acid loop (Fig. 1) [4]. ...
RTNs家族成员氨基端序列高度可变且大小显著不同,羧基端的约200个氨基酸残基则高度保守,被称为内质网蛋白同源结构域(reticulon-homologydomain,RHD)。RTNs高度可变的氨基端赋予其各成员物种特异性及细胞特异性的功能,羧基端的RHD则是其执行基本细胞功能的基础。越来越多的研究结果表明,RTNs可参与蛋白转运、参与膜结构形态...
Among all specific binding partners, our quantitative MS data point to the reticulon homology domain-containing proteins (RHPs) Rtn1p, Rtn2p, and Yop1p as the most abundant ER factors in the Pex30p complexes (Fig. 2A, 2D-plot, and supplemental Table S3A). The RHPs have been shown to ...
The structure of its reticulon-homology domain (RHD), an element shared with other ER-shaping proteins, and the mechanism of membrane shaping remain poorly understood. Using molecular modeling and molecular dynamics (MD) simulations, we assemble a structural model for the RHD of FAM134B. ...
Every reticulon contains the reticulon homology domain (RHD) at its C-terminal end and this domain is sufficient for partitioning and oligomerizing in the high curvature ER. The RHD contains two short hairpin membrane domains (MD) that are predicted to generate membrane curvature by increasing ...
哺乳动物基因组中有 RTN1,RTN2,RTN3及RTN4共四类相互独立的基因,因启动子及选择性剪接方式不同每个基因可产生不同转录本.RTNs家族成员氨基端序列高度 可变且大小显著不同,羧基端的约200个氨基酸残基则高度保守,被称为内质网蛋白同源结构域(reticulon-homology domain,RHD).RTNs高度可变的氨基端赋予其各成员物种特异...