Here we report updated interim results from the first-in-human phase 1 evaluation of autologous NKTs co-expressing a GD2-specific CAR with interleukin 15 (IL15) (GD2-CAR.15) in 12 children with neuroblastoma (NB
Claudin18.2 (CLDN18.2) is highly expressed with the development of various malignant tumors, especially gastrointestinal cancers, and is emerging as a new target for cancer treatment. Satricabtagene autoleucel (satri-cel)/CT041 is an autologous chimeric antigen receptor (CAR) T cell targeting CL...
However, the trend varied between different provinces. Estimates of the prevalence of malnutrition in 2020 also indicated a decrease in the prevalence of all indicators among children. Conclusion Despite the decreasing trend in malnutrition over the past three decades, the prevalence of stunting, ...
Currently, there is no comprehensive picture of the global surveillance landscape. This survey examines the current state of surveillance systems, levels of integration, barriers and opportunities for the integration of surveillance systems at the country level, and the role of national public health in...
9,11,12 The albumin–bilirubin (ALBI) grade is a novel and validated nomogram of liver function assessment in patients with HCC. It is based solely on serum albumin and bilirubin and therefore excludes evaluation of the subjective variables and confounding factors (ascites and encephalopathy) to ...
An intriguing aspect that emerged in recent years is the transition phase from psoriasis (PsO) to psoriatic arthritis (PsA). The PRESTO instrument allows e
Fourth quarter Adjusted EBITDA loss was$6.1 million, which is an improvement of$13.1 millioncompared to the prior year period. As part of the Company’s previously-discussed evaluation of its Asian supply chain, the Company announced the closure of itsSingaporemanufacturing facility in Dec...
Out of 17,337 non-HCQ users, 1,222 had at least a baseline and follow-up HAQ-DI evaluation, while 1,003 of those 1,222 (82.1%) also had at least a baseline and follow-up CHFS evaluation. After propensity score matching, 150 control patients were retained for the HAQ-DI analysis ...
With the rise of LLMs, there has been a surge in evaluation benchmarks, many of which focus on assessing LLMs’ capabilities in scientific domains. Most benchmarks evaluate core knowledge retrieval and reasoning abilities, which are typically backward-looking (Fig.1). Backward-looking benchmark...
A. et al. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nat. Med. 4, 321–327 (1998). Article CAS PubMed PubMed Central Google Scholar Download references Acknowledgements We acknowledge the following people for ...