- 《Circulation Research》 被引量: 1862发表: 2007年 SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Insulin resistance is often characterized as the most critical factor contributing to the development of type 2 diabetes. SIRT1 has been reported to be inv...
Fig. 4: KIR2DL1 and HLA-C*05 interaction alters uterine spiral arteries. aRepresentative uteroplacental circulation from WT × C*05 mating at gd10.5 visualized following perfusion with an X-ray contrast agent and imaging by micro-CT. Spiral arteries are shown in dark purple and the yolk...
function, stability, and/or macromolecular interactions39,41,42. The persulfidation process generally involves: (1) oxidation such as sulfenylation of the cysteine residue(s) on the targeted protein followed by nucleophilic attack of the oxidized thiol and/or disulfide by H2S, or (2) ...
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A similar neutral lipid exchange likely occurs with HDL whereby TAG-rich HDL is hydrolyzed by lipoprotein lipase resulting in the generation of smaller HDL particles that are rapidly removed from the circulation. In this way, elevated TAG resulting from disruption in insulin function, plays a ...
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Calorie restriction (CR) is defined as a reduction in calorie intake below the usual ad libitum intake without malnutrition. Ample of clinical and experimental evidence has demonstrated that CR is capable of retarding aging process and development of car
Cancer incidence increases with age and is a leading cause of death. Caloric restriction (CR) confers benefits on health and survival and delays cancer. However, due to CR’s stringency, dietary alternatives offering the same cancer protection have becom