of considerations to be used in appraising a logical system.Finally, the vicious circle principle is argued for on the basis of considerations, which are presumed evident, about the nature of propositional functions.The stringency of this principle is a basic problem for the system of Principia ...
WooCommerce integration, profile completeness, social activity, MailChimp, friends, etc. The good thing about plugin extensions is that you can add only the functions you need without bloating your site with code from those you don’t. On the downside, the extensions don’t come cheap, costing...
Epithelial membrane protein 3 (EMP3) is anN-glycosylated tetraspanin with a putative trafficking function. It is highly expressed in isocitrate dehydrogenase-wild-type glioblastoma (IDH-wt GBM), and its high expression correlates with poor survival. However, the exact trafficking role of EMP3 and h...
These levels are consistent with those thought to exist in type II PKA signaling domains following agonist stimulation, however, they are closer to esti- mated basal levels of endogenous cAMP throughout much of the remainder of the cell49. It has been estimated that mammalian cardiac myocytes ...
The insulin like growth factor II mRNA binding protein 3 (IGF2BP3) is one of the RBPs that contains 6 RNA-binding domains, including 2 RNA recognition motifs (RRM) at the N-terminus and 4 hnRNPK homology (KH) domains at the C-terminus. Existing studies have shown that IGF2BP3 ...
Emerin also functions as a negative regulator of gene expression by trapping transcriptional activators at the nuclear membrane. For example, the direct interaction of emerin with β-catenin causes the downregulation of Wnt signaling [22]. In the absence of emerin, the levels of nuclear β-catenin...
We previously showed that Sec15, an effector of th... Heidi,Hehnly,Chun-Ting,... - 《Current Biology》 被引量: 118发表: 2012年 Two appendages homologous between basal bodies and centrioles are formed using distinct Odf2 domains Ciliogenesis is regulated by context-dependent cellular cues, ...
LINE-1 type Transposase Domain-containing 1 (L1TD1/ECAT11), the sole known example of functional domestication of LINE-1-derived protein sequence, contains two ORF1-like domains. L1TD1 is associated with self-renewal and the maintenance of pluripotency in embryonic stem cell culture (although ...
LINE-1 type Transposase Domain-containing 1 (L1TD1/ECAT11), the sole known example of functional domestication of LINE-1-derived protein sequence, contains two ORF1-like domains. L1TD1 is associated with self-renewal and the maintenance of pluripotency in embryonic stem cell culture (although ...
The cellular functions of actin result from the ability of monomers to polymerize into filaments. In G-actin, the two main domains are located parallel to one other. The F-actin, formed as a result of polymerization, has a helical structure. The initial step of polymerization requires rotation...