While studies have identified key regulators of GPX4-restricted LPO and cellular demise1,2,6,12,13,14, mechanism(s) of concurrent inflammatory responses remain elusive. Inflammatory bowel diseases (IBDs) and specifically Crohn’s disease (CD) are characterized by chronic remittent intestinal inflammat...
IL-33 has also emerged as a key driver of type 1 immune responses. It is released by fibroblastic reticular cells in lymphoid organs and promotes clonal expansion and activation of antiviral CTLs and T-helper 1 (Th1) cells to confer protection against replicating viruses23,24,25,26,27. Mor...
Genome-wide chromatin state underlies gene expression potential and cellular function. Epigenetic features and nucleosome positioning contribute to the accessibility of DNA, but widespread regulators of chromatin state are largely unknown. Our study inve
Hotspot driver mutations presented by human leukocyte antigens might be recognized by anti-tumor T cells. Based on their advantages of tumor-specificity and immunogenicity, neoantigens derived from hotspot mutations, such as PIK3CAH1047L, may serve as emerging targets for cancer immunotherapies. NetMHC...
(BOLD) MRI makes use of paramagnetic properties of deoxyhemoglobin and is mainly used for regional quantification of oxygenation of the brain [25]. Long scanning times due to its intrinsic low sensitivity and proneness to motion artifacts, however, complicate its use in the abdomen [26]. ...
Use of the RU486-inucuble driver ruled out the possibility that the hearts of Hand4.2-GAL4 > or TinC-GAL4 > UAS-TER94RNAi flies performed poorly exclusively as a result of disrupted cardiogenesis. VCP is therefore likely required for development of cardiomyocytes and for the maintenance of ...