While studies have identified key regulators of GPX4-restricted LPO and cellular demise1,2,6,12,13,14, mechanism(s) of concurrent inflammatory responses remain elusive. Inflammatory bowel diseases (IBDs) and specifically Crohn’s disease (CD) are characterized by chronic remittent intestinal inflammat...
IL-33 has also emerged as a key driver of type 1 immune responses. It is released by fibroblastic reticular cells in lymphoid organs and promotes clonal expansion and activation of antiviral CTLs and T-helper 1 (Th1) cells to confer protection against replicating viruses23,24,25,26,27. Mor...
Use of the RU486-inucuble driver ruled out the possibility that the hearts of Hand4.2-GAL4 > or TinC-GAL4 > UAS-TER94RNAi flies performed poorly exclusively as a result of disrupted cardiogenesis. VCP is therefore likely required for development of cardiomyocytes and for the maintenance of ...