We set out to investigate the mechanisms by which variants in the voltage sensor (S4) of KCNQ3 impact channel function to cause NDDs9,10,11. Two missense mutations in the voltage sensor (S4) segment of the KCNQ3 channel, R227Q and R236C (Fig.1A), were introduced into the KCNQ3 chan...
Figures and plots were generated using VMD, PyMOL (2.6, Schrödinger, LLC) and the Matplotib (3.7.0) Python package112. Statistical analysis Results are presented as mean ± SEM or SD with the number of experiments indicated. Statistical analysis was performed using two-tailed Student’...
© 2025 HealthCentral LLC. All rights reserved. Introduction The use of highly active antiretroviral therapy (HAART) regimens has markedly improved the long-term prognosis of people living with HIV infection. However, HIV disease and its treatment are associated with metabolic complications, including...
Owing to rapid population aging, patients with dysphagia are significantly increasing in society. Dysphagia treatment is aimed at the restoration of the swallowing function and the prevention of recurrent aspiration-induced pulmonary infection. However,