Stress response pathways detect and alleviate adverse conditions to safeguard cell and tissue homeostasis, yet their prolonged activation induces apoptosis and disrupts organismal health1–3. How stress responses are turned off at the right time and plac
Living systems sometimes experience abrupt tipping points in response to stress. Here we investigate the factors contributing to the appearance of such abrupt state transitions in animal societies. We first construct a mathematical account of how the personality compositions of societies could alter their...
Molecular Responses to Stress Thecellular stress responsewas first dubbed theheat shock response. At least four decades ago, work with fruit flies revealed that transient heat exposure elicited a unique pattern of chromosomal puffing. Later, heat-induced changes inchromosomal structurewere associated with...
Size-scale transition from ductile to brittle failure: structural response vs. crack growth resistance curve. Int J Fract 1991; 51: 175-186.Carpinteri, A. (1991). Size-scale transition from ductile to brittle failure: structural response vs. crack growth resistance curve. International Journal ...
we assessed momentary perceived stress with a one-item visual analogue scale (VAS), which has been used previously (Fischer et al.2016; Linnemann et al.2015). Thereby, the participants responded to the item “I feel stressed” on a VAS ranging from 1 (completely disagree) to 100 (complete...
Osmotic stress poses one of the most fundamental challenges to living cells. Particularly, the largely inextensible plasma membrane of eukaryotic cells easily ruptures under in-plane tension calling for sophisticated strategies to readily respond to osmotic stress. We describe how epithelial cells react ...
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stress response, tissue regeneration and remodelling, muscle hypertrophy, as well as angiogenesis; whereas down-regulated genes significantly enriched a list of GO terms and KEGG pathways relevant to mitochondrial structure and oxidative phosphorylation activity, proteolysis, and transcription and translation ...
Studies have shown that phosphorylation participates in many molecular events and biological processes, such as DNA transcription, stomatal closure12, stress response and defense, and energy metabolism13. Recently, large-scale in vivo phosphoproteomic analyses have been performed to elucidate diverse ...
Ubiquitination is a post-translational modification initiated by the E1 enzyme UBA1, which transfers ubiquitin to ~35 E2 ubiquitin-conjugating enzymes. While UBA1 loss is cell lethal, it remains unknown how partial reduction in UBA1 activity is endured. Here, we utilize deep-coverage mass spectrom...