complete set minus ions, silver, pristine metals and functionalized metals versus complete set (y-axis represents the gene positions in the rank minus ions, silver, pristine metals and functionalized metals) (e). The fit is reported with a red line. In the top left boxes, theR2and thePvalu...
ROS, reactive oxygen species. c–e, Number of intestinal peroxisomes, assessed by fluorescence, following MUFA accumulation in worms expressing a peroxisome-localized GFP (GFP–SKL) driven by the intestinal ges-1 promoter (ges-1p::GFP–SKL). c, Zoomed-in images of the intestine. Scale bar, ...
A hallmark of traumatic brain injury and neurodegenerative diseases is the irreversible loss of neurons, leading to cognitive and functional deficits.1 Neurodegeneration is often associated with mitochondrial dysfunction,2,3 causing mitochondrial stress and excessive reactive oxygen species (ROS).2,3 These...
Anti-infectious agent: A substance (such as a chemical compound, protein, antisense oligonucleotide, or other molecule) of use in treating infection of a subject. Anti-infectious agents include, but are not limited to, anti-fungals, anti-virals, and antibiotics. Animal: Living multi-cellular ve...
2012) and revealed modifications in gene expression after 3 days of exposure to iron excess concerning genes involved in hormonal signaling but also those involved in C-compound and carbohydrate metabolism, oxygen and electron transfer, oxidative stress, and iron homeostasis and transport in indica ...
sachets, cachets, elixirs, suspensions, emulsions, solutions, syrups, aerosols (as a solid or in a liquid medium), ointments containing for example up to 10% by weight of the active compound, soft and hard gelatin capsules, suppositories, sterile injectable solutions and sterile packaged powders...
Cells were pretreated with splitomicin or compound C and then stimulated with PE, either alone or together with NAD. The hypertrophic response of cardiomyocytes was examined by measuring [3H]leucine incorporation into total cellular protein. The results showed that pretreatment of cells with compound...
Ligand-driven modulation of the mitochondrial translocator protein 18 kDa (TSPO) was recently described to dampen the neuroinflammatory response of microglia in a retinal light damage model resulting in protective effects on photoreceptors. We charact
Resetting tumor-associated macrophages (TAMs) is a promising strategy to ameliorate the immunosuppressive tumor microenvironment and improve innate and adaptive antitumor immunity. Here we show that chloroquine (CQ), a proven anti-malarial drug, can func
8A, box). A lysine residue (Lys-418) that is located outside the cavity forms a hydrogen-bonding interaction with the carbonyl oxygen of the amide bond within lacosamide. Another hydrogen bond is seen between the amide nitrogen of LCM and a glutamic acid (Glu-359) in the binding site. ...