27,33 Thus, ATF4 expression requires both the presence of sufficient ATF4 mRNA as well as efficient uORF bypass that depends on a persistent demand for the ternary complex by initiating ribosomes and a reduction in ternary complex supply, mediated by eIF2α-P. Analysis of mRNA levels in ...
aPKCs are known to regulate apical-basal polarity in epithelial cells, which is essential for maintaining epithelial structure and integrity22,23. In cancer, the prevailing notion is that cell polarity is lost; however, different members of this protein network are known to be involved in several...
Novel pipeline identifies new upstream ORFs and non-AUG initiating main ORFs with conserved amino acid sequences in the 5′ leader of mRNAs in Arabidopsis thaliana. RNA. 2019;25:292–304. Article PubMed Central PubMed Google Scholar Gage JL, Mali S, McLoughlin F, Khaipho-Burch M, Monier...
To evaluate the usefulness of the newly discovered alkaline pH-regulatable promoters for industrial application we sought to assess the amount of mRNA generated in comparison with that of genes whose expression is driven from well-known constitutive promoters widely used for heterologous protein production...
Regenerative potential is widespread but unevenly distributed across animals. However, our understanding of the molecular mechanisms underlying regenerative processes is limited to a handful of model organisms, restricting robust comparative analyses. He
By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your perso...
showed that induction chemotherapy in AML induced a transient senescence-like state in resilient cells that was capable of initiating AML recurrence42. ATF3 has been shown to be critical among the AP-1 transcription factors in reconstructing the accessibility of chromatin to promote senescence43. ...
For initiating SOCE, we reintroduced calcium by changing the medium to preconditioned medium after 1 hour or 2 hours of ERCa2+D (referred to as “SOCE” in the figures). If indicated, we added 20 μM of the CRAC-inhibitor GSK-7975A in the last medium change. RealTime-Glo cell ...
Neoadjuvant immunochemotherapy (nICT) has dramatically changed the treatment landscape of operable esophageal squamous cell carcinoma (ESCC), but factors influencing tumor response to nICT are not well understood. Here, using single-cell RNA sequencing p
Prior to initiating therapy, midfoot circumference was 9.25 inches bilaterally. After 10 months of treatment, midfoot circumference was 8.75 inches bilaterally. Interestingly, small subcutaneous nodules were first noted on exam after 3 months of imatinib therapy. They remain stable and nonprogressive, ...