When the crystal was tilted away from this orientation a marked decrease in contrast occurred with the familiar result that stacking faults become more difficult to observe. Stacking faults in dark field images, on the other hand, exbihited good contrast and were thus relatively easy to observe...
Neoantigen predictions were derived by first determining the 4-digit HLA type for each patient, along with mutations in class I HLA genes, using POLYSOLVER (Shukla et al., 2015). Next, all possible 9, 10 and 11-mer mutant peptides were computed, based on the detected somatic non-synonymous...
Box and Behnken introduced a class of three-level design forresponse analysis. BBD is developed by combination of 2kfactorials based upon incomplete block designs. When the points lie on the center of the cube, it become very much difficult to examine as the process is much expensive; but by...
Signalling through the IL-10 receptor regulates several steps of the immune response, from decreasing cytokine gene expression to down-regulating the expression of major histocompatibility complex class II (MHC-II) and thus antigen presentation to T cells [39, 40]. Furthermore, IL-10 has been ...
[1], although the most abundant and well-characterized belong to the intracellular nucleotide-binding/leucine-rich-repeat (NLR) class [3]. These receptors detect pathogen or herbivore effectors and evoke a defense response, effector-triggered immunity (ETI) that shares common signaling events and ...
Afferent low-threshold c-fibre mechanoreceptors (CLTM) are a class of highly specialised unmyelinated peripheral nerves that, when stimulated by a low force, low velocity ‘caressing’ stimulus delivered at skin temperature, induce a state of positive affect1,2,3. Microneurography recordings from ...
For example, standard manipulations usually test stimulus prop- erties in performance, which define different word classes. A general basis of many word-class distinctions is ambiguity. Ambiguity refers to the relative consistency of relations between spelling patterns and pronunciations, among other thi...
The Significance Analysis of Microarrays (SAM) algorithm[31] was used to perform two-class comparisons between groups (e.g. pIC 6HPI@10°C vs. pIC 6HPI@16°C) in order to identify differentially expressed genes (at FDR = 1%). Prior to SAM analysis, all probes that were absent in...
Several cell surface and soluble molecules typically used for immune recognition and signaling, such as the major histocompatibility complex class I (MHC-I), component 3 of the complement system (C3), or Toll-like receptors type 2 (TLR-2), become upregulated and/or activated within lesioned ...
For each ChIP-seq factor, time point, interaction class (increased, decreased, or non-responsive), we first calculated the mean of the normalized ChIP-seq signal at the anchors of each interaction. We then used these values to regress TF occupancy onto CTCF occupancy. To test the relationship...