doi:10.1001/archpsyc.58.2.148 Abstract Background We sought to determine whether the brain dysmorphology previously observed cross-sectionally in people with schizophrenia progresses over time and whether such progression is related to the severity of the illness course. Subjects and Methods Men with ...
As there are many ongoing studies with therapeutic candidates, it is of major interest to develop biomarkers not only to facilitate early diagnosis but also as a monitoring tool to predict disease progression and to enable correct randomization of patients in clinical trials. Magnetic resonance ...
4), EYO is a more precise indicator of disease progression, given that it tightly aligns with disease stage, whereas age does not. It is for this reason that we do not recommend using age and EYO in the same models. Given the family structure of the individuals within the DIAN cohort, ...
F. et al. Widespread age-related differences in the human brain microstructure revealed by quantitative magnetic resonance imaging. Neurobiol. Aging 35, 1862–1872 (2014). Article Google Scholar Fox, N. C. et al. Imaging of onset and progression of Alzheimer’s disease with voxel-compression ...
- 《European Archives of Psychiatry & Clinical Neuroscience》 被引量: 68发表: 1997年 Genetic and neurological evaluation in a sample of individuals with pervasive developmental disorders. inborn errors of metabolism, cytogenetic and molecular study of the FRAXA, FRAXE, and FRAXF mutations, EEG, ...
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Moreover, sMRI can be used to monitor disease progression by serially quantifying lesion size and location (Roy and Pandit, 2011). Not all epileptic seizures are caused by underlying structural abnormalities; however, those that are – such as FCD and mesial temporal lobe epilepsy (mTLE) – ...
, 2008). Because MRI is capable of characterizing multiple physical phenomena in cartilage, it is an auspicious technology to diagnose OA initiation and progression in vivo. Importantly, while MRI may be considered a gold standard technique to diagnose advanced OA, the development of specialized ...
We suggest that MRI of NM can be used to confirm PD diagnosis and monitor disease progression. We recommend that for subjects at risk for PD, and perhaps generally for older people, that MRI sequences performed at regular intervals can provide a pre-clinical means to detect presymptomatic PD....
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