GRAM-negative bacteriaBETA-lactamase inhibitorsENZYME inhibitorsANTIBIOTICSIn recent years, new antimicrobials have been introduced in therapeutics, including new beta-lactam-beta-lactamase inhibitor combinations and cefiderocol in response to therapeutic needs in the face of increasing re...
In an interview with Pharmacy Times, Thomas Lodise, PharmD, PhD, discussed new guidance released by the Infectious Diseases Society of America (IDSA) on the treatment of antimicrobial resistant gram-negative infections. The guidelines were reviewed in...
Shorter courses of antimicrobial therapy have been shown to be non-inferior to longer durations for the management of several infections. However, data on critically ill patients with severe infections by multidrug-resistant Gram-negative bacteria (MDR-G
Rapid initiation of effective antibiotic therapy has been strongly associated with a decrease in mortality in gram-negative (GN) bacteremia. In an effort to improve time to effective antibiotic therapy in the treatment of multi-drug resistant (MDR) GN bacteremia, we implemented Verigene GN Blood ...
Emergence of colistin-resistant gram-negative rods in intensive care units: a cross-sectional study from a developing country SAGE Open Med, 10 (2022), Article 20503121221132358 Google Scholar [22] P. Dawadi, S. Bista, S. Bista, J.G. Chediack Prevalence of colistin-resistant Escherichia coli...
Background: Colistin, a polymyxin with excellent in vitro activity against multidrug resistant gram negative bacilli (MDRGN), has experienced resurgence in usage due to the emergence of health-care associated MDRGN bacteria worldwide. The primary goal of our study was to evaluate efficacy of colist...
However, there is no new agents on the immediate horizon for the treatment of resistant gram-negative organisms. There are some agents in pre-clinical studies, but it will be 10-15 years before any of them may be available for clinical use. This places pressure on maintaining the ...
I Eurofins Medinet - 《Idsa》 被引量: 0发表: 2008年 In Vitro Activity of Tigecycline against Multiple-Drug-Resistant, Including Pan-Resistant, Gram-Negative and Gram-Positive Clinical Isolates from Greek Hos... The in vitro activities of tigecycline and selected antimicrobials were evaluated against...
Various studies have shown that dual carbapenem combinations have in vitro synergistic effects on carbapenem-resistant gram-negative bacterial infections [38]. The combination of ETP with another carbapenem was prompted by the evidence that ETP, as a suicide antibiotic, could bind to the active site...
McGowan JE Jr (2006) Resistance in nonfermenting gram-negative bacteria: multidrug resistance to the maximum. Am J Med 119(6 Suppl 1):S29–S36; discussion S62-70 PubMed CAS Google Scholar Hirsch EB, Tam VH (2010) Impact of multidrug-resistant Pseudomonas aeruginosa infection on patient outc...