The therapeutic relationship itself can be used as an intervention to explore relevant issues in cognitive therapy. That is, the relationship can be the means to help certain patients identify, understand, and change cognitions and metacognitions which, in turn, may lead to more satisfying and ...
are inconsistent with the prevalent assumption of resistance achieved through a single (epi)mutational change, which converts tolerance to resistance, and instead support a gradual improvement of cell fitness under therapy. Next, we decided to characterize the mechanistic underpinning of the evolution ...
Prevailing views of resistance to change tell a one-sided story that favors change agents by proposing that resistance is an irrational and dysfunctional reaction located "over there" in change recipients. We tell the rest of the story by proposing that change agents contribute to the occurrence ...
This paper presents an analysis of resistance to change in family therapy — a concept central to the understanding of drop-outs. The resistances used were categorized as Resistance to Therapy, Resistance to Interaction and Family Specific Resistances. Family behaviour was conceptualized as governed by...
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Chemotherapy is an essential treatment in the management of breast cancer. • Chemotherapy is carried out based on the selection of regimens for the specific individual and tumor characteristics. • Combination therapy, monitoring, and evaluation are used to prevent chemoresistance. ...
Effect Size Calculation To calculate Hedges d effect sizes, the mean change for the control was subtracted from the mean change for RET, and the difference was divided by the pooled baseline SD.31 Larger reductions in depressive symptoms for RET resulted in positive effect sizes. eTable 2 in...
"MTOR is a sensor protein that tells normal cells to stop growing because there is a stress in the environment. But we found that in the presence of a cancer treatment, MTOR signaling allowed cancer cells to change expression of genes involved in DNA repair and replication, for example shifti...
Advances in nano-immunotherapy for hematological malignancies Jian Xu Wenqi Liu Yu Hu Experimental Hematology & Oncology(2024) Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia Elena J. Orlando Xia Han
proband case is shown. R136S homozygous mutation can be observed, resulting from a change from cytosine (C) to adenine (A). In bottom panel a R136S heterozygous mutation from a descendant is identified. Data representative ofn = 2 independent experiments and further validated independently wi...