Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population. J. Immunol. 176, 2079–2083 (2006). Article CAS PubMed Google Scholar Hoekstra, M. E., Vijver, S. V. & Schumacher, T. N. Modulation of the tumor micro-environment by CD8+ T cell-...
Department of Molecular and Cellular Hemostasis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands Teunis J. P. van Dam Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA ...
Tissue-resident memory T cells (TRM) are a subset of T cells that play a crucial role in protecting resident tissues from secondary infections caused by pathogen. Recent studies leveraging single-cell transcriptomics have investigated the characteristics and functional roles of CD8+TRMin liver diseases...
Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, Pharm-X Center, Research Center for Small Molecule Immunological Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China Lei Sun, Haibo Zhang, Huihui Zhang, Xinyi Lou, Zhiming Wang, Xinyi Yang, ...
While T-cell responses to cancer immunotherapy have been avidly studied, long-lived memory has been poorly characterized. In a cohort of metastatic melanoma survivors with exceptional responses to immunotherapy, we probed memory CD8+ T-cell responses acr
Shey (University of Iowa Flow Cytometry Core Facility) for cell sorting, I. Antoshechkin (California Institute of Technology) and Admera health for RNA-seq. Data herein were obtained from the Flow Cytometry Facility, which is a Carver College of Medicine Core Research Facilities/Holden ...
GBIF data portal (2011). Royal British Columbia Museum; Ontario Breeding Bird Atlas 2001–2005; Macaulay Library—Audio Data, Bird Collection; Peabody Ornithology DiGIR Service, Bird Tissue Collection; University of Alberta Museums, Ornithology Collection; Project FeederWatch; eBird Bird Observation ...
In this Opinion article, we discuss the function of tissues as a crucial checkpoint for the regulation of effector T cell responses, and the notion that interleukin-15 (IL-15) functions as a danger molecule that communicates to the immune system that the tissue is under attack and poises it...
Briefly, mice were anaesthetized and the portal vein was cannulated. The liver was first digested with 0.5 mM EGTA and then digested with 0.05% collagenase IV, the digested liver resuspension was passed a 200-gauge steel mesh and the hepatocytes in the flow through were isolated by 40% ...
R. et al. Cutting edge: tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection. J. Immunol. 187, 5510–5514 (2011) . Article CAS Google Scholar Wu, T. et al. Lung-resident memory CD8 T cells (TRM) are indispensable for optimal cross-...