Respiratory viral infections reprogram pulmonary macrophages with altered anti-infectious functions. However, the potential function of virus-trained macrophages in antitumor immunity in the lung, a preferential target of both primary and metastatic mali
While T-cell responses to cancer immunotherapy have been avidly studied, long-lived memory has been poorly characterized. In a cohort of metastatic melanoma survivors with exceptional responses to immunotherapy, we probed memory CD8+ T-cell responses acr
Background Both liver natural killer (NK) and NK T cells of the innate immune system play a crucial role in islet graft loss after intraportal islet transplantation, although a relationship between NK and NK T cells in islet loss has not been proven. In this study, we inves...
Of the 185 remaining actives, 71 compounds have a developmental status (according to National Center for Advancing Translational Sciences [NCATS] portal for drug development information; https://drugs-01.ncats.io/; Table S1C). We focused our efforts on five FDA-approved drugs for further assessme...
(vector sequence #6363; https://www.addgene.org/browse/sequence_vdb/6363/); scRNA-seq data in the GEO for human T cells (accession GSE126030) and mouse lung ILCs (GSE102299); and the Biomart database (from Ensembl version 101; http://aug2020.archive.ensembl.org/biomart/martview/) for...
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Tissue-resident memory CD8+ T cells (TRM cells) are crucial in protecting against reinvading pathogens, but the impact of reinfection on their tissue confinement and contribution to recall responses is unclear. We developed a unique lineage tracer mouse
We acknowledge the hard work of all of the collaborators involved in the Avian Knowledge Network, Global Biodiversity Information Facility (GBIF) data portal and the Palaeoclimate Modelling Intercomparison Project Phase II (PMIP2). A special thanks to all of the museums who kindly provided tissue ...
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