psoriatic arthritistumor necrosis factorEtanercept is a fully human soluble recombinant p75 TNF receptor that blocks the binding of TNF to cell surface receptors, thereby neutralizing its biologic activity. Data supporting the FDA's approval of etanercept for controlling signs and symptoms and for ...
Psoriatic arthritis is a multigenic autoimmune disease that involves synovial tissue, entheseal sites and skin, and that may result in significant joint damage. Although there are no diagnostic tests for psoriatic arthritis, research has identified consistent features that help to distinguish the conditi...
Psoriatic Arthritis: Body weight loss of 5-10% was reported in 10% (49/497) of patients taking Otezla and in 3.3% (16/495) of patients taking placebo Behçet's Disease: Body weight loss of >5% was reported in 4.9% (5/103) of patients taking Otezla and in 3.9% (4...
Gender differences in biologic treatment outcomes—a study of 1750 patients with psoriatic arthritis using Danish Health Care Registers. Rheumatology. 2018;57:1651–60. PubMed Google Scholar Orbai AM, Perin J, Gorlier C, Coates LC, Kiltz U, Leung YY, et al. Determinants of patient-reported...
The study aimed to assess 52-week efficacy and safety of secukinumab self-administration by autoinjector in patients with active psoriatic arthritis (PsA) in the FUTURE 3 study ( ClinicalTrials.gov NCT01989468). Patients (≥ 18 years of age; N = 414)
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“In this study, we determined the effect of biologic treatment (TNFi and IL-17i) and MTX on serum CXCL10, MMP3, S100A8, ACP5, and CCL2 in psoriatic arthritis (PsA) patients,” Offenheim and colleagues concluded.1“Our results highlight that MMP3, S100A8, ACP5 and CXCL10, have po...
Therapeutic glucocorticoids also have actions in other forms of arthritis including ankylosing spondylitis which affects the anterior ligament and facet joints of the spine;13psoriatic arthritis, a chronic inflammatory joint disease associated with psoriasis;14septic arthritis, which results from bacterial or...
et al. Molecular mimicry of an HLA-B27-derived ligand of arthritis-linked subtypes with chlamydial proteins. J. Biol. Chem. 277, 37573–37581 (2002). Article CAS Google Scholar Ryu, K. H. et al. Tonsil-derived mesenchymal stromal cells: evaluation of biologic, immunologic and genetic ...
The anti-TNF agents have been shown to be of benefit in, and currently have indications for, RA (etanercept, infliximab, adalimumab), Crohn's disease (infliximab), and psoriatic arthritis (etanercept). Because the spondyloarthropathies share pathogenetic mechanisms with the above-specified disease ...