Cognitive domains that predict time to diagnosis in prodromal Huntington disease. J Neurol Neurosurg Psychiatry 2012; 83: 612-19.Harrington DL, Smith MM, Zhang Y, Carlozzi NE, Paulsen JS. Cognitive domains that predict time to diagnosis in prodromal Huntington disease. J Neurol Neurosurg ...
The creation of new medical knowledge can thus have many “starting points” in addition to basic science, thus challenging the linearity implied in many discussions and policies on TR. In their study of laboratory and clinical practices related to Huntington Disease, Lewis, Hughes, and Atkinson,...
Unlike conventional localization of GPCRs on cell plasma membrane, the majority of GPR56 was localized in the cytoplasm of PANC-1 cells and pre- sented in a pattern of scattered spots. When PANC-1 cells were treated with protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (...
The UK Government's White Paper on Genetics has suggested that as the science advances, testing for genetic susceptibilities could, in the future, become a routine part of primary prevention of common diseases, such as heart disease, diabetes and cancer [3, 4]. There are currently very few v...
The UK Government's White Paper on Genetics has suggested that as the science advances, testing for genetic susceptibilities could, in the future, become a routine part of primary prevention of common diseases, such as heart disease, diabetes and cancer [3, 4]. There are currently very few ...
Abstract Metabolism and redox signalling share critical nodes in the nervous system. In the last years, a series of major findings have challenged the current vision on how neural reactive oxygen species (ROS) are produced and handled in the nervous system. Once regarded as deleterious by-products...
Background Deterioration of cognitive functioning is a debilitating symptom in many neurodegenerative diseases, such as Huntington's disease (HD). To date, there are no effective treatments for the cognitive problems associated with HD. Cognitive assessment outcomes will have a central role in the ...
Tailoring an Evidence-Based Practice to Parents Raising Preschoolers with Autism: Strengths, Challenges, and Future Research DirectionsParent/Caregiver deliveredRelationshipbasedS. DababnahE. OlsonS. HuntingtonM. Sermon