BACKGROUND: No methodology is currently available to allow the combining of individual risk factor information derived from different longitudinal studies for a chronic disease in a multivariate fashion. This paper introduces such a methodology, named Synthesis Analysis, which is essentially a multivariate...
The keywords "cancer" and "long non-coding RNAs (LncRNAs)" emerged as the most prominent research topics in recent years.Future research on ferroptosis-related diseases, including cancer, heart failure, type 2 diabetes, and Alzheimer's disease, should further investigate the regulatory mechanisms ...
In this Journal Club article, María Ávila-Arcos discusses a paper on a medically relevant genetic variant that was found exclusively in Indigenous populations from the Americas. She describes how this work served as inspiration for the inclusion of more diverse populations in the 1000 Genomes Pro...
Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single-cell resolution This paper develops two approaches for multiplexing cortical organoids and SCanSNP, a method for deconvolving cell identities, to trace neurodevelopmental trajectories at scale. Nicolò ...
updated guidance for reporting clinical prediction models that use regression or machine learning methods British Medical Journal Publishing Group, The BMJ, 2024 Ann Robinson’s research reviews—2 February 2023 Ann Robinson, The BMJ, 2023 Powered by This Issue Views 14,232 Citations 36 43 Download...
The application of genomic data reflects, to some extent, the great potential and development direction of artificial intelligence in the field of disease prediction. As shown in Table 3, some algorithms for disease prediction and analysis are listed. It is expected that the future application of ...
In addition, the authors performed sub-group analyses finding an RR for ischemic heart disease of 1.23 (95% CI 1.07–1.42; N = 11) and an RR for heart failure of 1.10 (95% CI 1.04–1.18; N = 2). Xu et al. found an RR of 1.21 (95% CI 1.13–1.29; N = 2) when considering...
Masks for the public: laying straw men to rest Trisha Greenhalgh April 28, 2020 This paper responds to one by Graham Martin and colleagues, who offered a critique of my previous publications on masks for the lay public in the Covid-19 pandemic. I address their charges that my co-authors...
Unlike most previous review papers on “Alzheimer’s disease detection” [18], we paid more attention to these papers which used deep learning methods to analyze speech data of elderly people in different health states (AD, MCI, and HC). Therefore, we used the following keywords for paper ...
The Pooled Cohort Equations (PCEs) are race- and sex-specific Cox proportional hazards (PH)-based models used for 10-year atherosclerotic cardiovascular disease (ASCVD) risk prediction with acceptable discrimination. In recent years, neural network models have gained increasing popularity with their ...