在慢性心力衰竭(CHF)和2型糖尿病(T2D)患者中,钠-葡萄糖协同转运蛋白2(SGLT2)抑制可改善心肾功能,但对不同体液量亚群的影响细节仍不完整。 Methods This was a post hoc analysis of patients with CHF and T2D in the CANDLE trial ...
https://doi.org/10.1007/s10584-014-1257-2 Article Google Scholar Thorarinsdottir TL, Sillmann J, Haugen M, Gissibl N, Sandstad M (2019) Evaluation of CMIP5 and CMIP6 simulations of historical surface air temperature extremes using proper evaluation methods. Environ Res Lett. https://...
Interestingly, the knockdown of a specific phosphatase that degrades S1P, sphingosine-1- phosphohydrolase-1 (SPP1), can also trigger a pro-survival type of autophagy. In contrast to SphK1 overexpression, autophagy induced by SPP1 downregulation was marked by the activation of endoplasmic reticulum...