1) (6, 7). Git1p, a member of the major facilitator superfamily of transport proteins (8), was originally isolated based upon its ability to confer growth to an inositol auxotroph supplied with GroPIns as its inositol source (6). Subsequent studies have shown that although inositol ...
Surprisingly, the disruption of SOCE apparatus through the simultaneous depletion of Stim1 and Stim2 fails to have a significant negative impact on phagosome acidification, and efferocytosis appears to proceed normally. It should be noted that the deletion of Stim1 and Stim2 does not prevent the...
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After passing through the TOM channel, precursors do not engage the presequence translocase, but use separate machinery for transport to and insertion into the IMM. In vitro, most proteins spontaneously fold into a unique, thermodynamically stable, three-dimensional conformation. Although the physical-...
The fluid-mosaic model proposed by Singer and Nicholson (35) has long been used to explain the organization of membrane. Lipid rafts are defined as the functional lipid microdomains, which consist of cholesterol, sphingolipid, and their associated proteins (32). Although their existence is still ...
Although initially identified due to their role in transport of unspliced viral RNA from the nucleus to the cytoplasm, regulatory proteins like Rev have been shown to possess other functions. Both HIV-1 Rev and Jaagsiekte sheep retrovirus (JSRV) Rej enhancegagtranslation [15,20]. HIV-1 Rev ...
The RNA-binding protein Staufen (Stau) was originally identified inDrosophilaas an mRNA transport factor required to establish the anterior–posterior axis of the embryo5,6. Together with proteins of the exon-junction complex (EJC) and the translational repressor Bruno it binds tooskarmRNA, which ...