Taken together, in addition to altering the stimulus of IL-6 trans-signalling, prolonged HFD feeding also led to altered expression of the T cell-intrinsic mediator of IL-6 trans-signalling, gp130. In light of these observed changes in components of IL-6 trans- signalling upon prolonged HFD...
Expression of Bmp4, a prominent mediator of Fgf8 signaling in the OFT myocardium, was also unaffected in the OFT or chamber myocardium of Fgf3/Fgf10 double mutants in E9.5–10.5 embryos (data not shown). Taken together, morphologic and marker analyses suggest that Fgf3 and Fgf10 are not ...
Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1. PLoS Genet 2013; 9: e1003310. 18. Bruinsma W, van den Berg J, Aprelia M, Medema RH. Tousled-like kinase 2 regulates recovery from a DNA damage-...
Caenorhabditis elegansis a free-living nematode with cosmopolitan distribution [1]. From its first isolation in 1900 by Emile Maupas, this 1-mm-long roundworm was described as a soil nematode. However, the worm is rarely found in pure soil but prefers humid patches that are rich in decaying ...
The regulation of chromatin structure is critical for a wide range of essential cellular processes. The Tousled-like kinases, TLK1 and TLK2, regulate ASF1, a histone H3/H4 chaperone, and likely other substrates, and their activity has been implicated in
Low-grade inflammation links obesity to insulin resistance through the activation of tissue-infiltrating immune cells. Interleukin-6 (IL-6) is a crucial regulator of T cells and is increased in obesity. Here we report that classical IL-6 signalling in T
Abreu CM, Kumar R, Hamilton D, Dawdy AW, Creavin K, Eivers S et al. Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1. PLoS Genet 2013; 9: e1003310. Article CAS Google Scholar Bruinsma W, van ...
If these actions are to be performed automatically, ACCUS must act as a mediator, that is, it must be able to translate the new security and privacy policy, received from the expert system, and it needs to generate the necessary commands and actions, adapted to the requirements of each ...
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