6K). Therefore, we concluded that ILC2 sense IL-33 directly to produce IL-5 and to maintain B1 cells development. Fig. 6: IL-33 triggers IL-5 production in ILC2 to stimulate B1 cells. a–d Flow cytometric plots and quantification of B1 cells in (a), the peritoneal lavage (Il33+/...
The first step of glutaminolysis leads to the deamidation of Gln to produce Glu and is catalyzed by mitochondrial glutaminase (GLS). The second step of glutaminolysis leads to the conversion of Glu to α-KG and is catalyzed by glutamate dehydrogenase (17) or aminotransferases (18). To date,...
Whereas the wild-type S/S eIF2α MEFs were 80% viable after growth in glucose-free medium, the viability of the homozygous A/A eIF2α mutant MEFs was reduced to 35% at 66 hr (Figure 2D). Thus, phosphorylation of eIF2α is an ER signaling pathway necessary for survival upon ER ...
OpgH is a transmem- brane glucosyl transferase catalyzing the linear β -1,2 glucose backbone from UDP-glucose in the presence of ACP. The periplasmic OpgG glucosyl-transferase branch β -1,6 glucose residues from this growing linear backbone and liberate OPGs, ranging from 4 to 12 ...
Severing enzymes and molecular motors extract tubulin from the walls of microtubules by exerting mechanical force on subunits buried in the lattice. However, how much force is needed to remove tubulin from microtubules is not known, nor is the pathway by
Sclerotial development is a vital stage in the life cycles of many fungal plant pathogens. In this study, the protein Ss-CAD, which contains three conserved domains of cinnamyl alcohol dehydrogenase (CAD), was found to be required for sclerotial developm
In the presence of glucose, the gene expression, protein level, and enzymatic activity of Pbmls were mildly stimulated by proline. Our results suggested that PbMLS condenses acetyl-CoA from both 2C sources (GC) and nitrogen sources (from proline and purine metabolism) to produce malate. The...
Sclerotial development is a vital stage in the life cycles of many fungal plant pathogens. In this study, the protein Ss-CAD, which contains three conserved domains of cinnamyl alcohol dehydrogenase (CAD), was found to be required for sclerotial developm
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Insect β4GalNAcT's may also be involved in synthesis of glycolipids, **The function of putative FucTC was based on the activity of the ortholog from mosquito (Anopheles gambiae)6. groups4–7. In contrast to vertebrates, insects usually produce complex N-glycans at lower levels compared to ...