Compared to their wild-type counterparts, PANX3-null osteoblasts secreted less extracellular ATP and failed to support plasma cells in vitro. The P2RX4-specific inhibitor 5-BDBD abrogated the impact of extracellular ATP on bone marrow plasma cells in vitro, depleted bone marrow plasma cells in ...
The redox reactions of the electron transport chain are directly coupled with the synthesis of ATP. True or false? The majority of ATP produced during cellular respiration is produced during glycolysis. True or False: Synthesis of ATP using the energy released as a proton diffuses down a ...
This is speculation and additional studies will be needed to determine whether the imaginary temperature has an equal importance with the real temperature in cellular metabolism, membrane energetics (microsomal monooxygenase and ATP synthesis) and ageing....
The ATP sensitive K+channel (KATP) is a nutrient sensing protein complex, and increasing KATP current (IKATP) contributes to myocardial protection during I/R injury15,16. CaMKII can reduce IKATP, at least in part, by augmenting sequestration of KATP from the sarcolemma to a cytoplasmic compart...
Mitochondria, eukaryotic organelles, produce energy in the form of adenosine 5′-triphosphate (ATP) in a process termed oxidative phosphorylation (for recent reviews, see Refs. 1, 2, 3). Under conditions of high proton motive force (ΔμH+), the F1F0-ATP synthase complex catalyzes the format...
ARGK-1 is an ortholog of mammalian creatine kinase, which maintains cellular ATP levels. We found that argk-1 is possibly a selective effector of rsks-1/S6K-mediated longevity and that overexpression of ARGK-1 extends C. elegans lifespan, in part by activating the energy sensor AAK-2/...
We have shown recently that the formation of this RNP complex in an avian hepadnavirus, the duck hepatitis B virus, depends on cellular factors that include the heat shock protein 90 (Hsp90). We now report that RNP formation also requires ATP hydrolysis and the function of p23, a ...
Extracellular Toxoplasma gondii tachyzoites do not require carbon source uptake for ATP maintenance, gliding motility and invasion in the first hour of their extracellular lifeToxoplasma gondiiExtracellular stageEnergy metabolismGlycolysisMotilityATPApicomplexan parasites undergo metabolic shifts in adaptation to ...
Pannexin 1 (Panx1) is involved in the spinal central sensitization process in rats with neuropathic pain, but its interaction with well-known, pain-related, ligand-dependent receptors, such as NMDA receptors (NMDAR) and P2X7 purinoceptors (P2X7R), remain