diffusion-based modeling vs. discriminative modeling 鉴于目前SD如此火爆,用它来做深度图的生成也是再自然不过的事情。事实上,SD里面已经包含了rich prior knowledge,所以做depth的生成也很自然,作者仅使用合成训练数据在单个GPU上进行几天的微调就完成了训练,并得到SOTA的效果! 方法十分简单,就是fine-tune SDv2 的...
Marigold: Repurposing Diffusion-Based Image Generators for Monocular Depth Estimation CVPR 2024 (Oral, Best Paper Award Candidate) This repository represents the official implementation of the paper titled "Repurposing Diffusion-Based Image Generators for Monocular Depth Estimation". ...
9. These strategies identify therapeutic candidates based on their impact on cell signaling, gene expression and disease phenotypes5,10,11,12. Machine learning has been used to analyze high-throughput molecular interactomes
13 performed meta-path based network mining on a constructed a heterogeneous network, named HetioNet, for drug repurposing. Also, Ruiz et al12. analyzed the network diffusion profile of drugs on their constructed Multi-scale Interactome (MSI) network and revealed that integrating gene ontology (...
The conclusions drawn from our baseline model can be transferable to transductive models such as the path-category-based technique in DDR or the network diffusion algorithm (random walk with restart) in DTINet, which reduces the confidence of their obtained results. These findings also promote the ...
3 mRNA diffusion and spatial cell type assignment analyses. a, Images highlighting the spots of the Array-seq slide that were under (orange) or outside (blue) of the two MOB sections which were profiled. b, Spatial plots of total UMIs detected per spot across both MOB Array-seq data ...
DLS of Hsp104 alone revealed species with a diffusion coefficient of ∼2.7 × 10−7 cm2/s and hydrodynamic radius (Rh) of ∼7–10 nm (Figure S4A), indicative of a hexamer and consistent with prior studies (Bosl et al., 2005, Narayanan et al., 2003, Sweeny et al., 2015). ...
The BBB allows the passage of water and lipid-soluble molecules by passive diffusion. Two major estimations for BBB permeability are therefore based on passive diffusion models based on logP and polar surface area (PSA) of compounds (Egan et al., 2000), or active transport via a P-...
diffusion profile of drugs on their constructed Multi-scale Interactome (MSI) network and revealed that integrating gene ontology (GO) annotations on biomedical network improved both DDA prediction performance and interpretability. A Graph Convolutional Network (GCN)-based drug repurposing model, biFusion...
Proof of concept experiments confirmed that rifampicin accumulation was an active process; residual accumulation was observed at low temperature (4 °C), probably associated with unspecific binding to the bacterial cell wall or passive diffusion, while a saturable active rifampicin uptake was observed...